Gene

dock4b

ID

ZDB-GENE-060130-74

Name

dedicator of cytokinesis 4b

Symbol

dock4b Nomenclature History

Previous Names

sb:eu488 (1)
si:ch211-284e3.1 (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase mediated signal transduction. Orthologous to human DOCK4 (dedicator of cytokinesis 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu488 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dock4b Human Ortholog

No data available

Associated With dock4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR027007	C2 DOCK-type domain
Domain	IPR027357	DOCKER domain
Domain	IPR032376	Dedicator of cytokinesis, N-terminal domain
Domain	IPR035769	Dedicator of cytokinesis 4, SH3 domain
Domain	IPR037014	Dedicator of cytokinesis protein 4, DHR2 domain
Domain	IPR037811	Dedicator of cytokinesis B, C2 domain
Domain	IPR046770	DOCKER, Lobe B
Domain	IPR046773	DOCKER, Lobe C
Family	IPR026791	Dedicator of cytokinesis
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR042455	Dedicator of cytokinesis, N-terminal, subdomain 1
Homologous_superfamily	IPR043161	Dedicator of cytokinesis, C-terminal, lobe A
Homologous_superfamily	IPR043162	Dedicator of cytokinesis, C-terminal, lobe C

Domain Details Per Protein

Protein	Length	Armadillo-type fold	C2 DOCK-type domain	C2 domain superfamily	Dedicator of cytokinesis	Dedicator of cytokinesis 4, SH3 domain	Dedicator of cytokinesis B, C2 domain	Dedicator of cytokinesis, C-terminal, lobe A	Dedicator of cytokinesis, C-terminal, lobe C	Dedicator of cytokinesis, N-terminal domain	Dedicator of cytokinesis, N-terminal, subdomain 1	Dedicator of cytokinesis protein 4, DHR2 domain	DOCKER domain	DOCKER, Lobe B	DOCKER, Lobe C	SH3 domain	SH3-like domain superfamily
UniProtKB:A0A286Y8M9 InterPro	1953
UniProtKB:A0A8M2BC66 InterPro	1930
UniProtKB:E9QJL8 InterPro	1977
UniProtKB:A0A8M2BC62 InterPro	1970
UniProtKB:A0A8M2BC87 InterPro	1938
UniProtKB:A0A0R4IT43 InterPro	1962
UniProtKB:A0A8M3B1G3 InterPro	1961

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dock4b-201 (1) Ensembl	Ensembl	6,111 nt	Select Tool ZFIN BLAST
mRNA	dock4b-203 (1) Ensembl	Ensembl	5,451 nt	Select Tool ZFIN BLAST
mRNA	dock4b-204 (1) Ensembl	Ensembl	10,118 nt	Select Tool ZFIN BLAST
mRNA	dock4b-205 (1) Ensembl	Ensembl	10,177 nt	Select Tool ZFIN BLAST
mRNA	dock4b-206 (1) Ensembl	Ensembl	10,150 nt	Select Tool ZFIN BLAST
mRNA	dock4b-207 (1) Ensembl	Ensembl	10,054 nt	Select Tool ZFIN BLAST
ncRNA	dock4b-002 (1) Ensembl	Ensembl	680 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations