Gene
zfpm2a
- ID
- ZDB-GENE-060130-4
- Name
- zinc finger protein, FOG family member 2a
- Symbol
- zfpm2a Nomenclature History
- Previous Names
-
- fog2a (1)
- zgc:152696
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and metal ion binding activity. Predicted to be involved in cell differentiation; heart development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in midbrain. Human ortholog(s) of this gene implicated in 46,XY sex reversal 9; congenital diaphragmatic hernia; myelodysplastic syndrome; and tetralogy of Fallot. Orthologous to human ZFPM2 (zinc finger protein, FOG family member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Walton et al., 2006
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| 46,XY sex reversal 9 | Alliance | 46XY sex reversal 9 | 616067 |
| congenital diaphragmatic hernia | Alliance | Diaphragmatic hernia 3 | 610187 |
| tetralogy of Fallot | Alliance | Tetralogy of Fallot | 187500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013087 | Zinc finger C2H2-type |
| Domain | IPR034731 | Zinc finger CCHC FOG-type |
| Domain | IPR049361 | Zinc finger protein ZFPM1/2, PR domain |
| Family | IPR039746 | FOG family |
| Homologous_superfamily | IPR036236 | Zinc finger C2H2 superfamily |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | FOG family | SET domain superfamily | Zinc finger C2H2 superfamily | Zinc finger C2H2-type | Zinc finger CCHC FOG-type | Zinc finger protein ZFPM1/2, PR domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q2QKJ9
|
1141 | ||||||
|
UniProtKB:F1R4T3
|
1142 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zfpm2a-201
(1)
|
Ensembl | 4,564 nt | ||
| mRNA |
zfpm2a-202
(1)
|
Ensembl | 1,126 nt | ||
| mRNA |
zfpm2a-203
(1)
|
Ensembl | 4,142 nt | ||
| mRNA |
zfpm2a-204
(1)
|
Ensembl | 402 nt | ||
| mRNA |
zfpm2a-205
(1)
|
Ensembl | 4,007 nt |
Interactions and Pathways
No data available
Plasmids
No data available