Gene

rock2b

ID

ZDB-GENE-060125-2

Name

rho-associated, coiled-coil containing protein kinase 2b

Symbol

rock2b Nomenclature History

Previous Names

cb64 (1)
sb:cb64 (1)
si:dkey-65b13.10
si:dkey-65b13.7 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have GTP-Rho binding activity and Rho-dependent protein serine/threonine kinase activity. Involved in Kupffer's vesicle development; epithelial cilium movement involved in determination of left/right asymmetry; and heart morphogenesis. Predicted to localize to centrosome and cytoplasm. Is expressed in several structures, including EVL; Kupffer's vesicle; forerunner cell group; hindbrain; and somite. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb64 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rock2b Human Ortholog

No data available

Associated With rock2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain	IPR015008	ROCK, Rho binding domain
Domain	IPR017892	Protein kinase, C-terminal
Domain	IPR037311	Rho-associated protein kinase 2, HR1 domain
Family	IPR020684	Rho-associated protein kinase 1/2
Family	IPR050839	Rho-associated Serine/Threonine Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR046349	C1-like domain superfamily

Domain Details Per Protein

Protein	Length	AGC-kinase, C-terminal	C1-like domain superfamily	PH-like domain superfamily	Pleckstrin homology domain	Protein kinase, ATP binding site	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Protein kinase, C-terminal	Protein kinase domain	Protein kinase-like domain superfamily	Rho-associated protein kinase 1/2	Rho-associated protein kinase 2, HR1 domain	Rho-associated Serine/Threonine Kinase	ROCK, Rho binding domain	Serine/threonine-protein kinase, active site
UniProtKB:A0A8M1NDD8 InterPro	1401
UniProtKB:A0A8M6YUR0 InterPro	1468
UniProtKB:A0A8M3AT74 InterPro	941
UniProtKB:A0A8M9PP57 InterPro	1346
UniProtKB:A0A8M9PP53 InterPro	1493
UniProtKB:A0A8M9PH50 InterPro	1471
UniProtKB:A0A8M6YWK7 InterPro	1426
UniProtKB:A0A8M9PSI1 InterPro	1413
UniProtKB:A0A8M9PBK6 InterPro	1478
UniProtKB:A0A8M6Z372 InterPro	1082

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rock2b-201 (1) Ensembl	Ensembl	735 nt	Select Tool
mRNA	rock2b-204 (1) Ensembl	Ensembl	4,206 nt	Select Tool ZFIN BLAST
mRNA	rock2b-206 (1) Ensembl	Ensembl	5,158 nt	Select Tool
ncRNA	rock2b-003 (1) Ensembl	Ensembl	801 nt	Select Tool
ncRNA	rock2b-004 (1) Ensembl	Ensembl	767 nt	Select Tool
ncRNA	rock2b-005 (1) Ensembl	Ensembl	473 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations