Gene
ripply1
- ID
- ZDB-GENE-060113-1
- Name
- ripply transcriptional repressor 1
- Symbol
- ripply1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Involved in negative regulation of DNA-templated transcription and somite rostral/caudal axis specification. Acts upstream of or within regulation of skeletal muscle tissue development and somite specification. Located in nucleus. Is expressed in several structures, including margin; paraxial mesoderm; presumptive paraxial mesoderm; shield; and somite. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 6. Orthologous to several human genes including RIPPLY2 (ripply transcriptional repressor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR028127 | Ripply family |
1 - 1 of 1
Domain Details Per Protein
| Protein | Length | Ripply family |
|---|---|---|
|
UniProtKB:B3DGI6
|
140 | |
|
UniProtKB:Q2WG80
|
140 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ripply1-202
(1)
|
Ensembl | 1,253 nt | ||
| mRNA |
ripply1-204
(1)
|
Ensembl | 872 nt | ||
| mRNA |
ripply1-205
(1)
|
Ensembl | 1,374 nt | ||
| ncRNA |
ripply1-003
(1)
|
Ensembl | 850 nt | ||
| ncRNA |
ripply1-004
(1)
|
Ensembl | 823 nt |
1 - 5 of 5
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-38K9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194134 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194160 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039108 (1) | 935 nt | ||
| Genomic | GenBank:BX530030 (1) | 180154 nt | ||
| Polypeptide | UniProtKB:B3DGI6 (1) | 140 aa |
- Yabe, T., Uriu, K., Takada, S. (2023) Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation. Nature communications. 14:21152115
- Hajiabadi, H., Mamontova, I., Prizak, R., Pancholi, A., Koziolek, A., Hilbert, L. (2022) Deep-learning microscopy image reconstruction with quality control reveals second-scale rearrangements in RNA polymerase II clusters. PNAS nexus. 1:pgac065pgac065
- Ban, H., Yokota, D., Otosaka, S., Kikuchi, M., Kinoshita, H., Fujino, Y., Yabe, T., Ovara, H., Izuka, A., Akama, K., Yamasu, K., Takada, S., Kawamura, A. (2019) Transcriptional autoregulation of zebrafish tbx6 is required for somite segmentation. Development (Cambridge, England). 146(18):
- Keskin, S., Simsek, M.F., Vu, H.T., Yang, C., Devoto, S.H., Ay, A., Özbudak, E.M. (2019) Regulatory Network of the Scoliosis-Associated Genes Establishes Rostrocaudal Patterning of Somites in Zebrafish. iScience. 12:247-259
- Wang, Z., Ding, Z.C., Xu, Q.H., Liu, J.X. (2019) Metabolism responses to silver nanoparticles stresses during zebrafish embryogenesis. Elsevier Science. 222:991-1002
- Kinoshita, H., Ohgane, N., Fujino, Y., Yabe, T., Ovara, H., Yokota, D., Izuka, A., Kage, D., Yamasu, K., Takada, S., Kawamura, A. (2018) Functional roles of the Ripply-mediated suppression of segmentation gene expression at the anterior presomitic mesoderm in zebrafish. Mechanisms of Development. 152:21-31
- LLeras Forero, L., Narayanan, R., Huitema, L.F.A., VanBergen, M., Apschner, A., Peterson-Maduro, J., Logister, I., Valentin, G., Morelli, L.G., Oates, A., Schulte-Merker, S. (2018) Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock. eLIFE. 7
- Wopat, S., Bagwell, J., Sumigray, K.D., Dickson, A.L., Huitema, L.F.A., Poss, K.D., Schulte-Merker, S., Bagnat, M. (2018) Spine Patterning Is Guided by Segmentation of the Notochord Sheath. Cell Reports. 22:2026-2038
- Yin, J., Lee, R., Ono, Y., Ingham, P.W., Saunders, T.E. (2018) Spatiotemporal Coordination of FGF and Shh Signaling Underlies the Specification of Myoblasts in the Zebrafish Embryo. Developmental Cell. 46:735-750.e4
- Qiu, J., Fan, X., Wang, Y., Jin, H., Song, Y., Han, Y., Huang, S., Meng, Y., Tang, F., Meng, A. (2016) Embryonic hematopoiesis in vertebrate somites gives rise to definitive hematopoietic stem cells. Journal of molecular cell biology. 8(4):288-301
1 - 10 of 28
Show