Gene

mapk10

ID

ZDB-GENE-051120-117

Name

mitogen-activated protein kinase 10

Symbol

mapk10 Nomenclature History

Previous Names

jnk3 (1)
zgc:123234

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable JUN kinase activity. Acts upstream of or within enteric nervous system development and liver development. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; enteric nervous system; eye; and heart. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human MAPK10 (mitogen-activated protein kinase 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mapk10 Human Ortholog

No data available

Associated With mapk10 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Conserved_site	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
Domain	IPR000719	Protein kinase domain
Family	IPR008351	Mitogen-activated protein (MAP) kinase, JNK
Family	IPR050117	Mitogen-activated protein kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Mitogen-activated protein kinase	Mitogen-activated protein (MAP) kinase, conserved site	Mitogen-activated protein (MAP) kinase, JNK	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:A0A8M9P3E5 InterPro	441
UniProtKB:A0A8M2B8D5 InterPro	475
UniProtKB:A4QP40 InterPro	384
UniProtKB:A0A8M3AWM8 InterPro	475
UniProtKB:A0A8M9PCS4 InterPro	425
UniProtKB:A0A8M2B8C2 InterPro	467
UniProtKB:Q32LV0 InterPro	430
UniProtKB:A0A8M1P270 InterPro	486
UniProtKB:A0A8M6YV43 InterPro	467
UniProtKB:A0A0R4IB91 InterPro	433
UniProtKB:A0A0R4I9H8 InterPro	384
UniProtKB:A0A8M6Z3P4 InterPro	434
UniProtKB:A0A0R4IKK9 InterPro	472
UniProtKB:A0A8M6YUI1 InterPro	433

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mapk10-201 (1) Ensembl	Ensembl	1,887 nt	Select Tool ZFIN BLAST
mRNA	mapk10-202 (1) Ensembl	Ensembl	1,419 nt	Select Tool ZFIN BLAST
mRNA	mapk10-203 (1) Ensembl	Ensembl	1,756 nt	Select Tool ZFIN BLAST
mRNA	mapk10-204 (1) Ensembl	Ensembl	1,779 nt	Select Tool ZFIN BLAST
mRNA	mapk10-206 (1) Ensembl	Ensembl	1,863 nt	Select Tool ZFIN BLAST
mRNA	mapk10-207 (1) Ensembl	Ensembl	861 nt	Select Tool ZFIN BLAST
mRNA	mapk10-208 (1) Ensembl	Ensembl	674 nt	Select Tool ZFIN BLAST
ncRNA	mapk10-006 (1) Ensembl	Ensembl	1,123 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations