Gene
camk2a
- ID
- ZDB-GENE-051113-72
- Name
- calcium/calmodulin-dependent protein kinase II alpha
- Symbol
- camk2a Nomenclature History
- Previous Names
-
- camk2a1 (1)
- zgc:112538
- zgc:123320
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Exhibits calmodulin-dependent protein kinase activity. Involved in heart jogging and protein autophosphorylation. Predicted to localize to cytoplasm and neuron projection. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 53 and autosomal recessive non-syndromic intellectual disability. Is expressed in brain; heart; somite; and tail bud. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112538 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 53 | Alliance | Intellectual developmental disorder, autosomal dominant 53 | 617798 |
| autosomal recessive intellectual developmental disorder 63 | Alliance | ?Intellectual developmental disorder, autosomal recessive 63 | 618095 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR013543 | Calcium/calmodulin-dependent protein kinase II, association-domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR032710 | NTF2-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Calcium/calmodulin-dependent protein kinase II, association-domain | NTF2-like domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q32PV2
|
478 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
camk2a-201
(1)
|
Ensembl | 1,976 nt | ||
| mRNA |
camk2a-202
(1)
|
Ensembl | 881 nt |
Interactions and Pathways
No data available
Plasmids
No data available