Gene
tcf3b
- ID
- ZDB-GENE-051113-64
- Name
- transcription factor 3b
- Symbol
- tcf3b Nomenclature History
- Previous Names
-
- tcf3a (1)
- zgc:113045
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have several functions, including DNA-binding transcription factor activity; bHLH transcription factor binding activity; and protein dimerization activity. Predicted to be involved in positive regulation of neuron differentiation and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in agammaglobulinemia and colorectal cancer. Orthologous to human TCF3 (transcription factor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| agammaglobulinemia 8A | Alliance | Agammaglobulinemia 8A, autosomal dominant | 616941 |
| agammaglobulinemia 8B | Alliance | Agammaglobulinemia 8B, autosomal recessive | 619824 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Neuronal Differentiation E-box Binding Transcription Factors |
|---|---|---|---|---|
|
UniProtKB:B1H1L4
|
652 | |||
|
UniProtKB:A0A8M2BHT8
|
634 | |||
|
UniProtKB:A0A8M3AMB2
|
651 | |||
|
UniProtKB:A0A8M3B5J8
|
627 | |||
|
UniProtKB:A0A0R4IMI6
|
635 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available