Gene
nedd4a
- ID
- ZDB-GENE-051005-2
- Name
- NEDD4 E3 ubiquitin protein ligase a
- Symbol
- nedd4a Nomenclature History
- Previous Names
-
- si:ch211-79l17.5
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have ubiquitin protein ligase activity. Involved in endothelial to hematopoietic transition and negative regulation of Notch signaling pathway. Predicted to localize to cytoplasm. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein ligase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zhang et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000008 | C2 domain |
| Domain | IPR000569 | HECT domain |
| Domain | IPR001202 | WW domain |
| Family | IPR024928 | E3 ubiquitin-protein ligase, SMURF1 type |
| Family | IPR050409 | E3 ubiquitin-protein ligase |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR035983 | HECT, E3 ligase catalytic domain |
| Homologous_superfamily | IPR036020 | WW domain superfamily |
Domain Details Per Protein
| Protein | Length | C2 domain | C2 domain superfamily | E3 ubiquitin-protein ligase | E3 ubiquitin-protein ligase, SMURF1 type | HECT domain | HECT, E3 ligase catalytic domain | WW domain | WW domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q3KRP0
|
910 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nedd4a-201
(1)
|
Ensembl | 7,630 nt | ||
| mRNA |
nedd4a-202
(1)
|
Ensembl | 1,086 nt |
Interactions and Pathways
No data available
Plasmids
No data available