Gene

hmbox1a

ID

ZDB-GENE-050913-89

Name

homeobox containing 1a

Symbol

hmbox1a Nomenclature History

Previous Names

hmbox1
zgc:114064

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have telomeric DNA binding activity. Predicted to be involved in positive regulation of telomerase activity and positive regulation of telomere maintenance via telomerase. Predicted to localize to nuclear chromosome, telomeric region. Orthologous to human HMBOX1 (homeobox containing 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Diotel et al., 2015

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hmbox1a Human Ortholog

No data available

Associated With hmbox1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001356	Homeodomain
Domain	IPR001387	Cro/C1-type helix-turn-helix domain
Domain	IPR006899	Hepatocyte nuclear factor 1, N-terminal
Domain	IPR044866	HNF-1, dimerization domain
Domain	IPR044869	HNF-1, POU-specific (POUs) atypical domain
Family	IPR040363	Homeobox-containing protein 1
Homologous_superfamily	IPR009057	Homedomain-like superfamily
Homologous_superfamily	IPR010982	Lambda repressor-like, DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Cro/C1-type helix-turn-helix domain	Hepatocyte nuclear factor 1, N-terminal	HNF-1, dimerization domain	HNF-1, POU-specific (POUs) atypical domain	Homedomain-like superfamily	Homeobox-containing protein 1	Homeodomain	Lambda repressor-like, DNA-binding domain superfamily
UniProtKB:A0A8M3AU36 InterPro	432
UniProtKB:A0A8M2BH68 InterPro	443
UniProtKB:A0A8M9PKV6 InterPro	430
UniProtKB:Q4V904 InterPro	441
UniProtKB:A0A8M2BH49 InterPro	442
UniProtKB:A0A8M9PNW0 InterPro	431