Gene
macroh2a2
- ID
- ZDB-GENE-050913-114
- Name
- macroH2A.2 histone
- Symbol
- macroh2a2 Nomenclature History
- Previous Names
-
- H2A2 (1)
- h2afy2
- im:6898017
- wu:fa14g05
- zgc:114051
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables transcription cis-regulatory region binding activity. Involved in brain development. Predicted to be located in chromosome and nucleus. Predicted to be part of nucleosome. Is expressed in brain; central nervous system; retina; and retinal ganglion cell layer. Orthologous to human MACROH2A2 (macroH2A.2 histone).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6898017 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Buschbeck et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Core histone macro-H2A | Core histone macro-H2A, macro domain | Histone-fold | Histone H2A | Histone H2A, C-terminal domain | Histone H2A/H2B/H3 | Macro domain | Macro domain-like |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q4V914
|
367 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
h2afy2-201
(1)
|
Ensembl | 2,001 nt | ||
| mRNA |
h2afy2-202
(1)
|
Ensembl | 678 nt | ||
| mRNA |
h2afy2-203
(1)
|
Ensembl | 897 nt | ||
| mRNA |
h2afy2-204
(1)
|
Ensembl | 883 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(macroh2a2:EGFP-macroh2a2) |
|
|
| 1 | Gonzalez-Munoz et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-343M8 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-98E8 | ZFIN Curated Data | |
| Encodes | EST | fa14g05 | ||
| Encodes | EST | IMAGE:6898017 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:114051 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025502 (1) | 2011 nt | ||
| Genomic | GenBank:CU929381 (1) | 139599 nt | ||
| Polypeptide | UniProtKB:Q4V914 (1) | 367 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | MACROH2A2 | 10 | Amino acid sequence comparison (1) |
- Gonzalez-Munoz, E., Arboleda-Estudillo, Y., Chanumolu, S.K., Otu, H.H., Cibelli, J.B. (2019) Zebrafish macroH2A variants have distinct embryo localization and function. Scientific Reports. 9:8632
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Lee, S.L.J., Horsfield, J.A., Black, M.A., Rutherford, K., Fisher, A., Gemmell, N.J. (2017) Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. BMC Genomics. 18:557
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gagnon, J.A., Valen, E., Thyme, S.B., Huang, P., Ahkmetova, L., Pauli, A., Montague, T.G., Zimmerman, S., Richter, C., Schier, A.F. (2014) Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs. PLoS One. 9:e98186
- Alghisi, E., Distel, M., Malagola, M., Anelli, V., Santoriello, C., Herwig, L., Krudewig, A., Henkel, C.V., Russo, D., and Mione, M.C. (2013) Targeting oncogene expression to endothelial cells induces proliferation of the myelo-erythroid lineage by repressing the notch pathway. Leukemia. 24(6):943-53
- Buschbeck, M., Uribesalgo, I., Wibowo, I., Rué, P., Martin, D., Gutierrez, A., Morey, L., Guigó, R., Lopez-Schier, H., and Di Croce, L. (2009) The histone variant macroH2A is an epigenetic regulator of key developmental genes. Nature structural & molecular biology. 16(10):1074-1079
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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