Gene

cisha

ID

ZDB-GENE-050907-1

Name

cytokine inducible SH2-containing protein a

Symbol

cisha Nomenclature History

Previous Names

cish
wu:fk57g04
zgc:154062 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have 1-phosphatidylinositol-3-kinase regulator activity. Involved in negative regulation of erythrocyte differentiation; negative regulation of lymphocyte differentiation; and negative regulation of receptor signaling pathway via JAK-STAT. Predicted to localize to phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Is expressed in blastomere; pronephric duct; thymus; and ventral wall of dorsal aorta. Orthologous to human CISH (cytokine inducible SH2 containing protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Lewis et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cisha Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Bacteremia, susceptibility to}	614383
		{Malaria, susceptibility to}	611162
		{Tuberculosis, susceptibility to}	607948

Associated With cisha Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000980	SH2 domain
Domain	IPR001496	SOCS box domain
Domain	IPR035887	CIS, SH2 domain
Homologous_superfamily	IPR036036	SOCS box-like domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Length	CIS, SH2 domain	SH2 domain	SH2 domain superfamily	SOCS box domain	SOCS box-like domain superfamily
UniProtKB:A0A8M2BDG1 InterPro	208
UniProtKB:Q08BW5 InterPro	212

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cish-201 (1) Ensembl	Ensembl	1,421 nt	Select Tool ZFIN BLAST
mRNA	cish-202 (1) Ensembl	Ensembl	1,038 nt	Select Tool ZFIN BLAST
mRNA	cish-203 (1) Ensembl	Ensembl	497 nt	Select Tool ZFIN BLAST
ncRNA	cish-004 (1) Ensembl	Ensembl	429 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations