Gene
tdp2b
- ID
- ZDB-GENE-050816-1
- Name
- tyrosyl-DNA phosphodiesterase 2b
- Symbol
- tdp2b Nomenclature History
- Previous Names
-
- tdp2
- ttrap
- ttrapl
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Exhibits DNA binding activity and tyrosyl-DNA phosphodiesterase activity. Involved in convergent extension involved in gastrulation; determination of left/right symmetry; and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to localize to PML body and cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 23. Is expressed in Kupffer's vesicle; forerunner cell group; and tail bud. Orthologous to human TDP2 (tyrosyl-DNA phosphodiesterase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157406 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Esguerra et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 23 | Alliance | Spinocerebellar ataxia, autosomal recessive 23 | 616949 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Endonuclease/exonuclease/phosphatase | Endonuclease/exonuclease/phosphatase superfamily | Tyrosyl-DNA phosphodiesterase 2-like | UBA-like superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q5XJA0
|
369 |
Interactions and Pathways
No data available
Plasmids