Gene

magi2a

ID

ZDB-GENE-050810-4

Name

membrane associated guanylate kinase, WW and PDZ domain containing 2a

Symbol

magi2a Nomenclature History

Previous Names

magi2
fb82g11
si:dkey-97c7.1 (1)
si:dkeyp-86a5.1
wu:fb82g11

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to enable SMAD binding activity; signaling receptor binding activity; and signaling receptor complex adaptor activity. Acts upstream of or within pronephric glomerulus development. Predicted to be located in cell junction. Predicted to be active in cytoplasm and dendrite. Is expressed in pronephric glomerulus. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Dong et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With magi2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nephrotic syndrome type 15	Alliance	Nephrotic syndrome, type 15	617609

Associated With magi2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020590	Guanylate kinase, conserved site
Domain	IPR001202	WW domain
Domain	IPR001478	PDZ domain
Domain	IPR008144	Guanylate kinase-like domain
Domain	IPR008145	Guanylate kinase/L-type calcium channel beta subunit
Domain	IPR041489	PDZ domain 6
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036020	WW domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	Guanylate kinase, conserved site	Guanylate kinase-like domain	Guanylate kinase/L-type calcium channel beta subunit	PDZ domain	PDZ domain 6	PDZ superfamily	P-loop containing nucleoside triphosphate hydrolase	WW domain	WW domain superfamily
UniProtKB:A0A8M6Z5C9 InterPro	1494
UniProtKB:A0A8M6YY15 InterPro	1283
UniProtKB:A0A8M6Z5D1 InterPro	1311
UniProtKB:A0A8M6YZJ4 InterPro	1428
UniProtKB:A0A8M6Z5Z3 InterPro	1427
UniProtKB:A0A8M6YY10 InterPro	1495
UniProtKB:A0A8M9PHB4 InterPro	1493
UniProtKB:A0A8M6YX18 InterPro	1494
UniProtKB:F1Q897 InterPro	1503
UniProtKB:A0A8M6YX22 InterPro	1312