Gene

dusp12

ID

ZDB-GENE-050626-91

Name

dual specificity phosphatase 12

Symbol

dusp12 Nomenclature History

Previous Names

zgc:114069

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to act upstream of or within dephosphorylation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human DUSP12 (dual specificity phosphatase 12).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa6832	Allele with one point mutation	Unknown	Premature Stop	ENU

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Sequence Targeting Reagents

No data available

Human Disease

Associated With dusp12 Human Ortholog

No data available

Associated With dusp12 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016130	Protein-tyrosine phosphatase, active site
Domain	IPR000340	Dual specificity phosphatase, catalytic domain
Domain	IPR000387	Tyrosine-specific protein phosphatases domain
Domain	IPR020422	Dual specificity protein phosphatase domain
Family	IPR016278	Dual specificity protein phosphatase 12

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Domain Details Per Protein

Protein	Length	Dual specificity phosphatase, catalytic domain	Dual specificity protein phosphatase 12	Dual specificity protein phosphatase domain	Protein-tyrosine phosphatase, active site	Protein-tyrosine phosphatase-like	Tyrosine-specific protein phosphatases domain
UniProtKB:Q4QRE0 InterPro	305
UniProtKB:F1QYI8 InterPro	305

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 2

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dusp12-201 (1) Ensembl	Ensembl	1,348 nt	Select Tool ZFIN BLAST
mRNA	dusp12-202 (1) Ensembl	Ensembl	934 nt	Select Tool ZFIN BLAST
mRNA	dusp12-203 (1) Ensembl	Ensembl	789 nt	Select Tool ZFIN BLAST
mRNA	dusp12-204 (1) Ensembl	Ensembl	529 nt	Select Tool ZFIN BLAST
mRNA	dusp12-205 (1) Ensembl	Ensembl	4,316 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH73-217K22	CU855759	ZFIN Curated Data
Contained in	BAC	CH211-267E7	AL954134	ZFIN Curated Data
Encodes	cDNA	MGC:114069	BC097131	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001025177 (1)	1385 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL954134 (1)	160551 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1QYI8 (1)	305 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	DUSP12	1	Ensembl:ENSG00000081721 Gene:11266 OMIM:604835 HGNC:3067	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Dusp12	1	Ensembl:ENSMUSG00000026659 MGI:1890614 Gene:80915	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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