Gene
ctss2.2
- ID
- ZDB-GENE-050626-55
- Name
- cathepsin S, ortholog 2, tandem duplicate 2
- Symbol
- ctss2.2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in immune response and proteolysis involved in cellular protein catabolic process. Predicted to localize to extracellular space and lysosome. Human ortholog(s) of this gene implicated in neuropathy. Is expressed in blood; macrophage; and yolk syncytial layer. Orthologous to human CTSS (cathepsin S).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112489 (11 images)
- MGC:111950 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR013201 | Cathepsin propeptide inhibitor domain (I29) |
| Domain | IPR039417 | Papain-like cysteine endopeptidase |
| Family | IPR013128 | Peptidase C1A |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | Cathepsin propeptide inhibitor domain (I29) | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine endopeptidase | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q566T8
|
330 | ||||||||
|
UniProtKB:A0A8M3ATF0
|
337 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ctss2.2-201
(1)
|
Ensembl | 1,267 nt | ||
| mRNA |
ctss2.2-203
(1)
|
Ensembl | 998 nt | ||
| ncRNA |
ctss2.2-002
(1)
|
Ensembl | 615 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- This gene and ctssb.1 (ZDB-GENE-050522-559) are located next to each other in the genome and appear to be the result of a tandem duplication. The tandem duplicates appear to be the orthologs of human CTSS and mouse Ctss based on amino acid identity and conserved location.