Gene

lats1

ID

ZDB-GENE-050523-2

Name

large tumor suppressor kinase 1

Symbol

lats1 Nomenclature History

Previous Names

si:dkey-181i3.5
wu:fc19a11
zgc:123219

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Involved in BMP signaling pathway; convergent extension involved in gastrulation; and secondary heart field specification. Is expressed in several structures, including head; heart; liver; pectoral fin; and pleuroperitoneal region. Orthologous to human LATS1 (large tumor suppressor kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Chen et al., 2009

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Chen et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lats1 Human Ortholog

No data available

Associated With lats1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
autosomal dominant polycystic kidney disease	lats1^{zf2211/zf2211}	standard conditions	Xu et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Domain	IPR049761	Serine/threonine-protein kinase , Mob-binding domain
Family	IPR050236	Serine/threonine-protein kinases, AGC
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	AGC-kinase, C-terminal	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Serine/threonine-protein kinase , Mob-binding domain	Serine/threonine-protein kinases, AGC
UniProtKB:A9JTE1 InterPro	632
UniProtKB:Q58FB8 InterPro	1068
UniProtKB:Q5RIL6 InterPro	1068

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	lats1-201 (1) Ensembl	Ensembl	7,030 nt	Select Tool
mRNA	lats1-202 (1) Ensembl	Ensembl	2,552 nt	Select Tool
mRNA	lats1-203 (1) Ensembl	Ensembl	3,297 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations