Gene
ctss2.1
- ID
- ZDB-GENE-050522-559
- Name
- cathepsin S, ortholog2, tandem duplicate 1
- Symbol
- ctss2.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in several processes, including positive regulation of apoptotic signaling pathway; positive regulation of peptidase activity; and proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space and lysosome. Is expressed in cardiac ventricle. Human ortholog(s) of this gene implicated in neuropathy. Orthologous to human CTSS (cathepsin S).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR013201 | Cathepsin propeptide inhibitor domain (I29) |
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Domain Details Per Protein
| Protein | Length | Cathepsin propeptide inhibitor domain (I29) | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine endopeptidase | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q502A6
|
330 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ctss2.1-201
(1)
|
Ensembl | 1,227 nt | ||
| ncRNA |
ctss2.1-002
(1)
|
Ensembl | 803 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-113G11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-30O16 | ZFIN Curated Data | |
| Contains | SNP | rs3728791 | ZFIN Curated Data | |
| Contains | SNP | rs3728792 | ZFIN Curated Data | |
| Contains | SNP | rs3728793 | ZFIN Curated Data | |
| Contains | SNP | rs3728794 | ZFIN Curated Data | |
| Contains | SNP | rs3728795 | ZFIN Curated Data | |
| Contains | SNP | rs3728796 | ZFIN Curated Data | |
| Contains | SNP | rs3728797 | ZFIN Curated Data | |
| Encodes | EST | fc38f10 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001024409 (1) | 1244 nt | ||
| Genomic | GenBank:BX248517 | 201353 nt | ||
| Polypeptide | UniProtKB:Q502A6 (1) | 330 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- This gene and ctssb.2 (ZDB-GENE-050626-55) are located next to each other in the genome and appear to be the result of a tandem duplication. The tandem duplicates appear to be the orthologs of human CTSS and mouse Ctss based on amino acid identity and conserved location.
- Vaz-Rodrigues, R., Mazuecos, L., Villar, M., Contreras, M., Artigas-Jerónimo, S., González-García, A., Gortázar, C., de la Fuente, J. (2023) Multi-omics analysis of zebrafish response to tick saliva reveals biological processes associated with alpha-Gal syndrome. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 168:115829115829
- Cadiz Diaz, A., Schmidt, N.A., Yamazaki, M., Hsieh, C.J., Lisse, T.S., Rieger, S. (2022) Coordinated NADPH oxidase/hydrogen peroxide functions regulate cutaneous sensory axon de- and regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2115009119
- Zhu, H., Wang, Z., Wang, W., Lu, Y., He, Y.W., Tian, J. (2022) Bacterial Quorum-Sensing Signal DSF Inhibits LPS-Induced Inflammations by Suppressing Toll-like Receptor Signaling and Preventing Lysosome-Mediated Apoptosis in Zebrafish. International Journal of Molecular Sciences. 23(13)
- Cavone, L., McCann, T., Drake, L.K., Aguzzi, E.A., Oprişoreanu, A.M., Pedersen, E., Sandi, S., Selvarajah, J., Tsarouchas, T.M., Wehner, D., Keatinge, M., Mysiak, K.S., Henderson, B.E.P., Dobie, R., Henderson, N.C., Becker, T., Becker, C.G. (2021) A unique macrophage subpopulation signals directly to progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord. Developmental Cell. 56(11):1617-1630.e6
- Demin, K.A., Lakstygal, A.M., Krotova, N.A., Masharsky, A., Tagawa, N., Chernysh, M.V., Ilyin, N.P., Taranov, A.S., Galstyan, D.S., Derzhavina, K.A., Levchenko, N.A., Kolesnikova, T.O., Mor, M.S., Vasyutina, M.L., Efimova, E.V., Katolikova, N., Prjibelski, A.D., Gainetdinov, R.R., de Abreu, M.S., Amstislavskaya, T.G., Strekalova, T., Kalueff, A.V. (2020) Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish. Scientific Reports. 10:19981
- Fang, Y., Lai, K.S., She, P., Sun, J., Tao, W., Zhong, T.P. (2020) Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion. Frontiers in cell and developmental biology. 8:738
- Lu, X., Xiang, Y., Yang, G., Zhang, L., Wang, H., Zhong, S. (2017) Transcriptomic characterization of zebrafish larvae in response to mercury exposure. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 192:40-49
- Münch, J., Grivas, D., González-Rajal, Á., Torregrosa-Carrión, R., de la Pompa, J.L. (2017) Notch signalling restricts inflammation and serpine1 expression in the dynamic endocardium of the regenerating zebrafish heart.. Development (Cambridge, England). 144(8):1425-1440
- Scheldeman, C., Mills, J.D., Siekierska, A., Serra, I., Copmans, D., Iyer, A.M., Whalley, B.J., Maes, J., Jansen, A.C., Lagae, L., Aronica, E., de Witte, P.A.M. (2017) mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis. Neurobiology of disease. 108:225-237
- Dong, X., Ye, Z., Song, L., Su, B., Zhao, H., Peatman, E., Li, C. (2016) Expression profile analysis of two Cathepsin S in channel catfish (Ictalurus punctatus) mucosal tissues following bacterial challenge. Fish & shellfish immunology. 48:112-8
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