Gene

ngly1

ID

ZDB-GENE-050522-535

Name

N-glycanase 1

Symbol

ngly1 Nomenclature History

Previous Names

im:6895151
zgc:110561 (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity. Predicted to be involved in glycoprotein catabolic process; protein deglycosylation; and protein quality control for misfolded or incompletely synthesized proteins. Predicted to localize to cytosol and nucleus. Human ortholog(s) of this gene implicated in NGLY1-deficiency. Orthologous to human NGLY1 (N-glycanase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6895151 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Mesika et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ngly1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital disorder of deglycosylation 1	Alliance	Congenital disorder of deglycosylation 1	615273

Associated With ngly1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002931	Transglutaminase-like
Domain	IPR006588	Peptide N glycanase, PAW domain
Domain	IPR018997	PUB domain
Family	IPR050883	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR036339	PUB-like domain superfamily
Homologous_superfamily	IPR038680	PAW domain superfamily
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily