Gene
c9
- ID
- ZDB-GENE-050522-442
- Name
- complement component 9
- Symbol
- c9 Nomenclature History
- Previous Names
-
- wu:fb60b05
- wu:fd50e04
- zgc:112272
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Acts upstream of or within cellular response to estrogen stimulus; defense response to bacterium; and immune response. Predicted to be located in extracellular region; membrane; and other organism cell membrane. Predicted to be part of membrane attack complex. Predicted to be active in extracellular space. Is expressed in liver and yolk syncytial layer. Human ortholog(s) of this gene implicated in age related macular degeneration 15 and complement component 9 deficiency. Orthologous to human C9 (complement C9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112272 (5 images)
- IMAGE:7140385 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 15 | Alliance | {Macular degeneration, age-related, 15, susceptibility to} | 615591 |
| complement component 9 deficiency | Alliance | C9 deficiency | 613825 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020863 | Membrane attack complex component/perforin domain, conserved site |
| Domain | IPR020864 | Membrane attack complex component/perforin (MACPF) domain |
| Family | IPR001862 | Membrane attack complex component/perforin/complement C9 |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Length | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A repeat | Membrane attack complex component/perforin/complement C9 | Membrane attack complex component/perforin domain, conserved site | Membrane attack complex component/perforin (MACPF) domain | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B8A565
|
673 |
Interactions and Pathways
No data available
Plasmids
No data available