Gene
gtpbp3
- ID
- ZDB-GENE-050522-335
- Name
- GTP binding protein 3, mitochondrial
- Symbol
- gtpbp3 Nomenclature History
- Previous Names
-
- zgc:112394 (1)
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have GTP binding activity and GTPase activity. Involved in embryonic organ development. Localizes to mitochondrion. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 23. Orthologous to human GTPBP3 (GTP binding protein 3, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112394 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
combined oxidative phosphorylation deficiency 23 | Alliance | Combined oxidative phosphorylation deficiency 23 | 616198 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
mitochondrial metabolism disease | AB + MO2-gtpbp3 | standard conditions | Chen et al., 2016 |
hypertrophic cardiomyopathy | gtpbp3zf2239/zf2239 (AB) | standard conditions | Chen et al., 2019 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR005225 | Small GTP-binding domain |
Domain | IPR006073 | GTP binding domain |
Domain | IPR018948 | GTP-binding protein TrmE, N-terminal |
Domain | IPR025867 | MnmE, helical domain |
Domain | IPR031168 | TrmE-type guanine nucleotide-binding domain |
Family | IPR004520 | tRNA modification GTPase MnmE |
Homologous_superfamily | IPR027266 | GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 |
Homologous_superfamily | IPR027368 | tRNA modification GTPase MnmE domain 2 |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
Protein | Length | GTP binding domain | GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 | GTP-binding protein TrmE, N-terminal | MnmE, helical domain | P-loop containing nucleoside triphosphate hydrolase | Small GTP-binding domain | TrmE-type guanine nucleotide-binding domain | tRNA modification GTPase MnmE | tRNA modification GTPase MnmE domain 2 |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q501Z5
|
500 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
gtpbp3-201
(1)
|
Ensembl | 1,664 nt | ||
mRNA |
gtpbp3-202
(1)
|
Ensembl | 818 nt | ||
mRNA |
gtpbp3-204
(1)
|
Ensembl | 1,557 nt | ||
mRNA |
gtpbp3-205
(1)
|
Ensembl | 1,889 nt | ||
mRNA |
gtpbp3-206
(1)
|
Ensembl | 1,344 nt | ||
ncRNA |
gtpbp3-003
(1)
|
Ensembl | 437 nt |
Interactions and Pathways
No data available
Plasmids
No data available