Gene
six6b
- ID
- ZDB-GENE-050522-308
- Name
- SIX homeobox 6b
- Symbol
- six6b Nomenclature History
- Previous Names
-
- si:dkey-225h23.3
- zgc:110344
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Involved in cell proliferation involved in compound eye morphogenesis. Predicted to localize to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in optic disc anomalies with retinal and/or macular dystrophy. Is expressed in hypothalamus. Orthologous to human SIX6 (SIX homeobox 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| optic disc anomalies with retinal and/or macular dystrophy | Alliance | Optic disc anomalies with retinal and/or macular dystrophy | 212550 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox protein SIX1, N-terminal SD domain | Homeodomain |
|---|---|---|---|---|
|
UniProtKB:Q5TYZ2
|
245 |
Interactions and Pathways
No data available
Plasmids
No data available