Gene

cep55l

ID
ZDB-GENE-050522-222
Name
centrosomal protein 55 like
Symbol
cep55l Nomenclature History
Previous Names
  • cep55 (1)
  • zgc:112184
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Acts upstream of or within cerebellum development; cranial skeletal system development; and regulation of intracellular signal transduction. Predicted to be located in several cellular components, including Flemming body; centriole; and cleavage furrow. Is expressed in several structures, including caudal fin; integument; nervous system; pleuroperitoneal region; and proliferative region. Used to study hydranencephaly and multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. Human ortholog(s) of this gene implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. Orthologous to human CEP55 (centrosomal protein 55).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cep55l Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly Alliance Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 236500
Associated With cep55l Via Experimental Models
Human Disease Fish Conditions Citations
hydranencephaly zf195Tg + MO2-cep55l standard conditions Frosk et al., 2017
hydranencephaly zf195Tg + MO3-cep55l standard conditions Frosk et al., 2017
hydranencephaly zf195Tg + CRISPR1-cep55l standard conditions Frosk et al., 2017
multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly cep55luy25/uy25 standard conditions Yanagi et al., 2019
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR022008 TSG101 and ALIX binding domain of CEP55
Family IPR038926 Centrosomal protein of 55kDa
Domain Details Per Protein
Protein Length Centrosomal protein of 55kDa TSG101 and ALIX binding domain of CEP55
UniProtKB:Q502I3
InterPro
435
UniProtKB:A0A8M2B241
InterPro
434
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cep55l-201 (1)
Ensembl
Ensembl 2,200 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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