Gene
cox5aa
- ID
- ZDB-GENE-050522-133
- Name
- cytochrome c oxidase subunit 5Aa
- Symbol
- cox5aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Exhibits cytochrome-c oxidase activity. Involved in embryonic organ development and spinal cord motor neuron differentiation. Predicted to localize to mitochondrial respiratory chain complex IV. Used to study ciliopathy and visceral heterotaxy. Is expressed in several structures, including adaxial cell; alar plate midbrain region; immature eye; musculature system; and nervous system. Orthologous to human COX5A (cytochrome c oxidase subunit 5A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb739 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial complex IV deficiency nuclear type 20 | Alliance | Mitochondrial complex IV deficiency, nuclear type 20 | 619064 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| visceral heterotaxy | WT + MO1-cox5aa | standard conditions | Burkhalter et al., 2019 |
| ciliopathy | WT + MO1-cox5aa | standard conditions | Burkhalter et al., 2019 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome c oxidase, subunit Va/VI | Cytochrome c oxidase, subunit Va/VI superfamily |
|---|---|---|---|
|
UniProtKB:Q4VBU7
|
141 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cox5aa-201
(1)
|
Ensembl | 690 nt | ||
| mRNA |
cox5aa-202
(1)
|
Ensembl | 457 nt |
Interactions and Pathways
No data available
Plasmids
No data available