Gene

lrp5

ID

ZDB-GENE-050518-2

Name

low density lipoprotein receptor-related protein 5

Symbol

lrp5 Nomenclature History

Previous Names

LRP6

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Acts upstream of or within several processes, including embryonic organ morphogenesis; neural crest cell migration; and neuromast hair cell development. Predicted to be located in membrane. Is expressed in several structures, including brain; head; pectoral fin bud; posterior lateral line primordium; and tail bud. Used to study nonsyndromic deafness. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Orthologous to several human genes including LRP5 (LDL receptor related protein 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 8 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 21 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lrp5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant osteopetrosis 1	Alliance	Osteopetrosis, autosomal dominant 1	607634
exudative vitreoretinopathy 4	Alliance	Exudative vitreoretinopathy 4	601813
osteoporosis-pseudoglioma syndrome	Alliance	Osteoporosis-pseudoglioma syndrome	259770
polycystic liver disease 4	Alliance	Polycystic liver disease 4 with or without kidney cysts	617875
Worth syndrome	Alliance	Endosteal hyperostosis	144750
		[Bone mineral density variability 1]	601884

Associated With lrp5 Via Experimental Models

Human Disease	Fish	Conditions	Citations
osteoporosis	AB + CRISPR3-lrp5	control	Bek et al., 2021
osteoporosis	lrp5^{sa11097/sa11097} (AB)	standard conditions	Bek et al., 2021
nonsyndromic deafness	WT + MO5-lrp5 + MO6-lrp5	standard conditions	Xia et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR000742	EGF-like domain
Family	IPR050778	Cueball/EGF/LRP/Nidogen
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
Repeat	IPR000033	LDLR class B repeat
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat

Domain Details Per Protein

Protein	Length	Cueball/EGF/LRP/Nidogen	EGF-like domain	LDLR class B repeat	LDL receptor-like superfamily	Low-density lipoprotein (LDL) receptor class A, conserved site	Low-density lipoprotein (LDL) receptor class A repeat	Six-bladed beta-propeller, TolB-like
UniProtKB:D0EWS1 InterPro	1430
UniProtKB:A0A8M3AZI2 InterPro	1613
UniProtKB:F1QTJ4 InterPro	1615

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	lrp5-201 (1) Ensembl	Ensembl	9,019 nt	Select Tool ZFIN BLAST
mRNA	lrp5-202 (1) Ensembl	Ensembl	4,390 nt	Select Tool ZFIN BLAST
mRNA	lrp5-203 (1) Ensembl	Ensembl	6,388 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations