Gene
abcg5
- ID
- ZDB-GENE-050517-40
- Name
- ATP-binding cassette, sub-family G (WHITE), member 5
- Symbol
- abcg5 Nomenclature History
- Previous Names
-
- sterolin 1
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in cholesterol efflux; cholesterol homeostasis; and transmembrane transport. Predicted to be located in membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in arteriosclerosis and sitosterolemia. Orthologous to human ABCG5 (ATP binding cassette subfamily G member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2683 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17622 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22240 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42150 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 4 of 4
Show
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| sitosterolemia 2 | Alliance | Sitosterolemia 2 | 618666 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR013525 | ABC-2 type transporter, transmembrane domain |
| Domain | IPR043926 | ABC transporter family G domain |
1 - 5 of 7 Show all
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ABC-2 type transporter, transmembrane domain | ABC transporter family G domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ATP-binding cassette subfamily G transporters | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B3DG12
|
652 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-227C6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193792 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193804 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128690 (1) | 2054 nt | ||
| Genomic | GenBank:AL928999 (1) | 169570 nt | ||
| Polypeptide | UniProtKB:B3DG12 (1) | 652 aa |
- Ellingsen, S., Narawane, S., Fjose, A., Verri, T., Rønnestad, I. (2021) The zebrafish cationic amino acid transporter/glycoprotein-associated family: sequence and spatiotemporal distribution during development of the transport system b0,+ (slc3a1/slc7a9). Fish physiology and biochemistry. 47(5):1507-1525
- Meng, H., Shang, Y., Cheng, Y., Wang, K., Yu, J., Cao, P., Fan, S., Li, Y., Cui, J. (2021) Knockout of zebrafish colony-stimulating factor 1 receptor by CRISPR/Cas9 affects metabolism and locomotion capacity. Biochemical and Biophysical Research Communications. 551:93-99
- Singh, M.K., Jayarajan, R., Varshney, S., Upadrasta, S., Singh, A., Yadav, R., Scaria, V., Sengupta, S., Shanmugam, D., Shalimar, ., Sivasubbu, S., Gandotra, S., Sachidanandan, C. (2021) Chronic systemic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liver. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(5):158905
- Wang, B., Liu, L., Li, Y., Zou, J., Li, D., Zhao, D., Li, W., Sun, W. (2021) Ustilaginoidin D induces hepatotoxicity and behaviour aberrations in zebrafish larvae. Toxicology. 456:152786
- Mi, X., Li, Z., Yan, J., Li, Y., Zheng, J., Zhaung, Z., Yang, W., Gong, L., Shi, J. (2020) Activation of HIF-1 signaling ameliorates liver steatosis in zebrafish atp7b deficiency (Wilson's disease) models. Biochimica et biophysica acta. Molecular basis of disease. 1866(10):165842
- Zhang, L., Fang, Y., Lu, X., Xu, S., Cai, F., Yu, M., Li, X., Zhong, S. (2020) Transcriptional response of zebrafish larvae exposed to lindane reveals two detoxification genes of ABC transporter family (abcg5 and abcg8). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 232:108755
- Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967
- Pinto, C.L., Kalasekar, S.M., McCollum, C.W., Riu, A., Jonsson, P., Lopez, J., Swindell, E., Bouhlatouf, A., Balaguer, P., Bondesson, M., Gustafsson, J.Å. (2016) Lxr regulates lipid metabolic and visual perception pathways during zebrafish development. Molecular and Cellular Endocrinology. 419:29-43
- Ren, J., Chung-Davidson, Y.W., Yeh, C.Y., Scott, C., Brown, T., Li, W. (2015) Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. BMC Genomics. 16:436
- Cruz-Garcia, L., Schlegel, A. (2014) Lxr-driven enterocyte lipid droplet formation delays transport of ingested lipids. Journal of Lipid Research. 55(9):1944-58
1 - 10 of 14
Show