Gene
abcc5
- ID
- ZDB-GENE-050517-17
- Name
- ATP-binding cassette, sub-family C (CFTR/MRP), member 5
- Symbol
- abcc5 Nomenclature History
- Previous Names
-
- fj51h02
- mrp5 (1)
- si:ch1073-183g13.2
- wu:fj51h02
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable ATPase-coupled transmembrane transporter activity. Acts upstream of or within erythrocyte differentiation and heme transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including female organism; liver; nervous system; pleuroperitoneal region; and solid lens vesicle. Orthologous to human ABCC5 (ATP binding cassette subfamily C member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Korolnek et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2950 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31027 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32218 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43168 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43169 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43170 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43171 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
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Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:E7EYG0
|
1426 | ||||||
|
UniProtKB:E1B2R7
|
1426 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-183G13 | ZFIN Curated Data | |
| Encodes | EST | fj51h02 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001195613 (1) | 4281 nt | ||
| Genomic | GenBank:FO905000 (1) | 110776 nt | ||
| Polypeptide | UniProtKB:E1B2R7 (1) | 1426 aa |
- Zhang, X., Xia, M., Su, X., Yuan, P., Li, X., Zhou, C., Wan, Z., Zou, W. (2021) Photolytic degradation elevated the toxicity of polylactic acid microplastics to developing zebrafish by triggering mitochondrial dysfunction and apoptosis. Journal of hazardous materials. 413:125321
- Moraes, J.S., da Silva Nornberg, B.F., Castro, M.R., Vaz, B.D.S., Mizuschima, C.W., Marins, L.F.F., Martins, C.M.G. (2020) Zebrafish (Danio rerio) ability to activate ABCC transporters after exposure to glyphosate and its formulation Roundup Transorb®. Chemosphere. 248:125959
- Lu, X., Tian, J., Wen, H., Jiang, M., Liu, W., Wu, F., Yu, L., Zhong, S. (2019) Microcystin-LR-regulated transcriptome dynamics in ZFL cells. Aquatic toxicology (Amsterdam, Netherlands). 212:222-232
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Lian, J., Chen, J., Wang, K., Zhao, L., Meng, P., Yang, L., Wei, J., Ma, N., Xu, J., Zhang, W., Zhang, Y. (2018) Alas1 is essential for neutrophil maturation in zebrafish. Haematologica. 103(11):1785-1795
- Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ren, J., Chung-Davidson, Y.W., Yeh, C.Y., Scott, C., Brown, T., Li, W. (2015) Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. BMC Genomics. 16:436
- Korolnek, T., Zhang, J., Beardsley, S., Scheffer, G.L., Hamza, I. (2014) Control of Metazoan Heme Homeostasis by a Conserved Multidrug Resistance Protein. Cell Metabolism. 19(6):1008-19
- Higdon, C.W., Mitra, R.D., and Johnson, S.L. (2013) Gene expression analysis of zebrafish melanocytes, iridophores, and retinal pigmented epithelium reveals indicators of biological function and developmental origin. PLoS One. 8(7):e67801
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