Gene
cdc6
- ID
- ZDB-GENE-050506-131
- Name
- cell division cycle 6 homolog (S. cerevisiae)
- Symbol
- cdc6 Nomenclature History
- Previous Names
-
- im:7145727 (1)
- zgc:174506
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA replication origin binding activity. Acts upstream of or within mitotic cell cycle phase transition. Predicted to be active in nucleus. Is expressed in central nervous system and proliferative region. Used to study Meier-Gorlin syndrome. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145727 (12 images)
- IMAGE:7153999 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Yao et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Meier-Gorlin syndrome 5 | Alliance | Meier-Gorlin syndrome 5 | 613805 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Meier-Gorlin syndrome | cdc6tsu21cd/tsu21cd | standard conditions | Yao et al., 2017 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR015163 | Cdc6, C-terminal |
| Domain | IPR054425 | Cdc6/ORC1-like, ATPase lid domain |
| Family | IPR016314 | Cell division protein Cdc6/18 |
| Family | IPR050311 | Origin Recognition Complex 1/Cell Division Control Protein 6 |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ATPase, AAA-type, core | Cdc6, C-terminal | Cdc6/ORC1-like, ATPase lid domain | Cell division protein Cdc6/18 | Origin Recognition Complex 1/Cell Division Control Protein 6 | P-loop containing nucleoside triphosphate hydrolase | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A8KC19
|
561 |
Interactions and Pathways
No data available
Plasmids
No data available