Gene

fat1a

ID

ZDB-GENE-050425-1

Name

FAT atypical cadherin 1a

Symbol

fat1a Nomenclature History

Previous Names

fat1
fat

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable calcium ion binding activity. Acts upstream of or within closure of optic fissure and pronephros development. Predicted to be located in membrane. Is expressed in several structures, including digestive system; nervous system; otic vesicle; pleuroperitoneal region; and tail bud. Human ortholog(s) of this gene implicated in colorectal cancer; esophagus squamous cell carcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and oral squamous cell carcinoma. Orthologous to human FAT1 (FAT atypical cadherin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu651 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fat1a Human Ortholog

No data available

Associated With fat1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Conserved_site	IPR020894	Cadherin conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR002126	Cadherin-like
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR039808	Cadherin
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR015919	Cadherin-like superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site

Domain Details Per Protein

Protein	Length	Cadherin	Cadherin conserved site	Cadherin-like	Cadherin-like superfamily	Concanavalin A-like lectin/glucanase domain superfamily	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Laminin G domain	NOTCH1 EGF-like calcium-binding domain
UniProtKB:A0A8M9PRG7 InterPro	4666
UniProtKB:A0A8M9PV49 InterPro	4643
UniProtKB:A2BGT8 InterPro	4611
UniProtKB:A0A8M2BFN2 InterPro	4634
UniProtKB:A0A8M2BG88 InterPro	4646