Gene
hcn4
- ID
- ZDB-GENE-050420-360
- Name
- hyperpolarization activated cyclic nucleotide-gated potassium channel 4
- Symbol
- hcn4 Nomenclature History
- Previous Names
-
- si:ch211-203b17.1
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable voltage-gated potassium channel activity. Acts upstream of or within heart contraction. Predicted to be located in plasma membrane. Predicted to be part of HCN channel complex. Predicted to be active in axon and dendrite. Is expressed in cardiovascular system. Used to study sick sinus syndrome. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; idiopathic generalized epilepsy; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Brugada syndrome 8 | Alliance | Brugada syndrome 8 | 613123 |
| sick sinus syndrome | Alliance | Sick sinus syndrome 2 | 163800 |
| {Epilepsy, idiopathic generalized, susceptibility to, 18} | 619521 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| sick sinus syndrome | twu34Tg + MO1-hcn4 | standard conditions | Jou et al., 2017 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR013621 | Ion transport N-terminal |
| Family | IPR051413 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Ion transport domain | Ion transport N-terminal | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7UQR8
|
1140 |
Interactions and Pathways
No data available
Plasmids
No data available