Gene
otogl
- ID
- ZDB-GENE-050419-93
- Name
- otogelin-like
- Symbol
- otogl Nomenclature History
- Previous Names
-
- si:dkeyp-27b10.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have alpha-L-arabinofuranosidase activity. Involved in otolith morphogenesis; semicircular canal morphogenesis; and sensory perception of sound. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 84B. Is expressed in inner ear; macula utricle; and otolith. Orthologous to human OTOGL (otogelin like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Yariz et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 84B | Alliance | Deafness, autosomal recessive 84B | 614944 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001846 | von Willebrand factor, type D domain |
| Domain | IPR002919 | Trypsin Inhibitor-like, cysteine rich domain |
| Domain | IPR006207 | Cystine knot, C-terminal |
| Domain | IPR007934 | Alpha-L-arabinofuranosidase B, arabinose-binding domain |
| Domain | IPR014853 | VWF/SSPO/Zonadhesin-like, cysteine-rich domain |
| Family | IPR050780 | Mucin/von Willebrand/Thrombospondin superfamily |
| Homologous_superfamily | IPR036084 | Serine protease inhibitor-like superfamily |
| Homologous_superfamily | IPR036195 | Alpha-L-arabinofuranosidase B, arabinose-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Alpha-L-arabinofuranosidase B, arabinose-binding domain | Alpha-L-arabinofuranosidase B, arabinose-binding domain superfamily | Cystine knot, C-terminal | Mucin/von Willebrand/Thrombospondin superfamily | Serine protease inhibitor-like superfamily | Trypsin Inhibitor-like, cysteine rich domain | von Willebrand factor, type D domain | VWF/SSPO/Zonadhesin-like, cysteine-rich domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q6S7
|
2556 | ||||||||
|
UniProtKB:A0A8M9P1M2
|
2513 |
Interactions and Pathways
No data available
Plasmids
No data available