Gene
gmds
- ID
- ZDB-GENE-050419-45
- Name
- GDP-mannose 4,6-dehydratase
- Symbol
- gmds Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Exhibits fucosyltransferase activity. Involved in Notch signaling pathway; central nervous system development; and retina layer formation. Predicted to localize to cytoplasm. Used to study congenital disorder of glycosylation type IIc. Human ortholog(s) of this gene implicated in open-angle glaucoma. Is expressed in EVL; corneal epithelium; neuromast; and periderm. Orthologous to human GMDS (GDP-mannose 4,6-dehydratase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63772 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital disorder of glycosylation type IIc | gmdsp31erb/p31erb | standard conditions | Song et al., 2010 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GDP-mannose 4,6-dehydratase | NAD(P)-binding domain | NAD(P)-binding domain superfamily |
|---|---|---|---|---|
|
UniProtKB:F1QPT3
|
377 | |||
|
UniProtKB:Q1LVF8
|
370 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | gmds-003 (1) | Havana | 886 nt | ||
| mRNA |
gmds-201
(1)
|
Ensembl | 1,693 nt | ||
| mRNA |
gmds-202
(1)
|
Ensembl | 1,712 nt | ||
| mRNA |
gmds-203
(1)
|
Ensembl | 2,083 nt | ||
| mRNA |
gmds-204
(1)
|
Ensembl | 880 nt | ||
| mRNA | ottdart00000002404 (1) | Havana | 509 nt | ||
| mRNA | ottdart00000002405 (1) | Havana | 907 nt |
Interactions and Pathways
No data available
Plasmids
No data available