Gene
ddb2
- ID
- ZDB-GENE-050419-169
- Name
- damage-specific DNA binding protein 2
- Symbol
- ddb2 Nomenclature History
- Previous Names
-
- si:dkey-45f10.3
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to contribute to damaged DNA binding activity. Predicted to be involved in DNA repair and response to UV. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group E. Is expressed in central nervous system and neurons. Orthologous to human DDB2 (damage specific DNA binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 11 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7165203 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
xeroderma pigmentosum group E | Alliance | Xeroderma pigmentosum, group E, DDB-negative subtype | 278740 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR019775 | WD40 repeat, conserved site |
Family | IPR033312 | DNA damage-binding protein 2 |
Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
Protein | Length | DNA damage-binding protein 2 | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
---|---|---|---|---|---|---|
UniProtKB:A0A8M9PLU3
|
280 | |||||
UniProtKB:A0A8M2B5I0
|
351 | |||||
UniProtKB:Q2YDS1
|
496 | |||||
UniProtKB:Z4YI04
|
497 | |||||
UniProtKB:A0A8M2B5L4
|
503 |
Interactions and Pathways
No data available
Plasmids
No data available