Gene

ttc23

ID

ZDB-GENE-050419-126

Name

tetratricopeptide repeat domain 23

Symbol

ttc23 Nomenclature History

Previous Names

si:dkey-25f3.1 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Orthologous to human TTC23 (tetratricopeptide repeat domain 23).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa17911	Allele with one point mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa43093	Allele with one point mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With ttc23 Human Ortholog

No data available

Associated With ttc23 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR042621	Tetratricopeptide repeat protein TTC23/TTC23L
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Repeat	IPR019734	Tetratricopeptide repeat

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Domain Details Per Protein

Protein	Length	Tetratricopeptide-like helical domain superfamily	Tetratricopeptide repeat	Tetratricopeptide repeat protein TTC23/TTC23L
UniProtKB:A0A8M9PVW5 InterPro	463
UniProtKB:A0A8M9PSU4 InterPro	462
UniProtKB:A0A8M2B5M5 InterPro	462
UniProtKB:A0A8M9PFU5 InterPro	463

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 18

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ttc23-201 (1) Ensembl	Ensembl	1,598 nt	Select Tool ZFIN BLAST
mRNA	ttc23-202 (1) Ensembl	Ensembl	1,126 nt	Select Tool ZFIN BLAST
mRNA	ttc23-203 (1) Ensembl	Ensembl	801 nt	Select Tool ZFIN BLAST
mRNA	ttc23-204 (1) Ensembl	Ensembl	686 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-25F3	BX470160	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_003200452 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	RefSeq:NW_018395340 (1)		Select Tool MegaBLAST
Polypeptide	UniProtKB:A0A8M9PFU5 (1)	463 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	TTC23	15	Ensembl:ENSG00000103852 Gene:64927 HGNC:25730	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Ttc23	7	Ensembl:ENSMUSG00000030555 MGI:1914259 Gene:67009	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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