Gene
gng2
- ID
- ZDB-GENE-050417-59
- Name
- guanine nucleotide binding protein (G protein), gamma 2
- Symbol
- gng2 Nomenclature History
- Previous Names
-
- zgc:110302
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable G-protein beta-subunit binding activity. Acts upstream of or within sprouting angiogenesis and vascular endothelial growth factor receptor signaling pathway. Located in cytosol and membrane. Is expressed in cardiovascular system and nervous system. Orthologous to human GNG2 (G protein subunit gamma 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110302 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | DNA/RNA polymerase superfamily | Domain of unknown function DUF5641 | G-protein gamma-like domain | G-protein gamma-like domain superfamily | G-protein, gamma subunit | Integrase, catalytic core | Integrase zinc-binding domain | Retrotransposon, Pao | Reverse transcriptase/Diguanylate cyclase domain | Reverse transcriptase domain | Ribonuclease H-like superfamily | Ribonuclease H superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QJN0
|
1954 | ||||||||||||
|
UniProtKB:Q15KE4
|
71 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-52K1 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110302 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192404 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001346274 (1) | 1344 nt | ||
| Genomic | GenBank:CR792443 (1) | 217981 nt | ||
| Polypeptide | UniProtKB:A0A8M9QJN0 (1) | 1954 aa |
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Tokarz, D.A., Heffelfinger, A.K., Jima, D.D., Gerlach, J., Shah, R.N., Rodriguez-Nunez, I., Kortum, A.N., Fletcher, A.A., Nordone, S.K., Law, J.M., Heber, S., Yoder, J.A. (2017) Disruption of Trim9 function abrogates macrophage motility in vivo. Journal of Leukocyte Biology. 102(6):1371-1380
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Aoki, M., Segawa, H., Naito, M., and Okamoto, H. (2014) Identification of possible downstream genes required for the extension of peripheral axons in primary sensory neurons. Biochemical and Biophysical Research Communications. 445(2):357-362
- Xu, H., Kardash, E., Chen, S., Raz, E., and Lin, F. (2012) Gβγ signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity. Development (Cambridge, England). 139(1):57-62
- Mulligan, T., Blaser, H., Raz, E., and Farber, S.A. (2010) Prenylation-deficient G protein gamma subunits disrupt GPCR signaling in the zebrafish. Cellular Signalling. 22(2):221-233
- Hippe, H.J., Wolf, N.M., Abu-Taha, I., Mehringer, R., Just, S., Lutz, S., Niroomand, F., Postel, E.H., Katus, H.A., Rottbauer, W., and Wieland, T. (2009) The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function. Proceedings of the National Academy of Sciences of the United States of America. 106(38):16269-16274
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
- Leung, T., Chen, H., Stauffer, A.M., Giger, K.E., Sinha, S., Horstick, E.J., Humbert, J.E., Hansen, C.A., and Robishaw, J.D. (2006) Zebrafish G protein γ2 is required for VEGF signaling during angiogenesis. Blood. 108(1):160-166
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