Gene

chrna5

ID

ZDB-GENE-050417-440

Name

cholinergic receptor, nicotinic, alpha 5

Symbol

chrna5 Nomenclature History

Previous Names

zgc:110642

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Predicted to be involved in several processes, including chemical synaptic transmission; monoatomic ion transmembrane transport; and regulation of membrane potential. Predicted to act upstream of or within monoatomic ion transport. Predicted to be located in postsynaptic membrane. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in interpeduncular nucleus tegmentum and liver. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cocaine abuse; esophagus squamous cell carcinoma; nicotine dependence; and respiratory system cancer (multiple). Orthologous to human CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Thyme et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With chrna5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Lung cancer susceptibility 2}	612052
		{Nicotine dependence, susceptibility to}	612052

Associated With chrna5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018000	Neurotransmitter-gated ion-channel, conserved site
Domain	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
Domain	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain
Family	IPR002394	Nicotinic acetylcholine receptor
Family	IPR006201	Neurotransmitter-gated ion-channel
Homologous_superfamily	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily
Homologous_superfamily	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Homologous_superfamily	IPR038050	Neuronal acetylcholine receptor

Domain Details Per Protein

Protein	Length	Neuronal acetylcholine receptor	Neurotransmitter-gated ion-channel	Neurotransmitter-gated ion-channel, conserved site	Neurotransmitter-gated ion-channel ligand-binding domain	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Neurotransmitter-gated ion-channel transmembrane domain	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Nicotinic acetylcholine receptor
UniProtKB:Q567Y7 InterPro	466
UniProtKB:A0A8M9P128 InterPro	439

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	chrna5-201 (1) Ensembl	Ensembl		1,752 nt	Select Tool ZFIN BLAST
mRNA	chrna5-202 (1) Ensembl	Ensembl		1,440 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: Jensen et al., 2010 reported conserved synteny between zebrafish and Human chrna5. However, analysis of the current genome build (Zv9) no longer supports the synteny relationship.

Citations