Gene
tfap2b
- ID
- ZDB-GENE-050417-394
- Name
- transcription factor AP-2 beta
- Symbol
- tfap2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in cartilage development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Char syndrome and patent ductus arteriosus. Is expressed in several structures, including basal plate midbrain region; nervous system; pharyngeal arch; pronephros; and ventral mesoderm. Orthologous to human TFAP2B (transcription factor AP-2 beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110163 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Zada et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Char syndrome | Alliance | Char syndrome | 169100 |
| Patent ductus arteriosus 2 | 617035 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Transcription factor AP-2 | Transcription factor AP-2 beta | Transcription factor AP-2, C-terminal |
|---|---|---|---|---|
|
UniProtKB:Q4TTV4
|
439 | |||
|
UniProtKB:A0A8M2B7U7
|
457 | |||
|
UniProtKB:Q561Y4
|
266 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available