Gene
prkar1ab
- ID
- ZDB-GENE-050417-238
- Name
- protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b
- Symbol
- prkar1ab Nomenclature History
- Previous Names
-
- zgc:112145
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cGMP-mediated signaling. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112145 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
acrodysostosis | Alliance | Acrodysostosis 1, with or without hormone resistance | 101800 |
Carney complex | Alliance | Carney complex, type 1 | 160980 |
primary pigmented nodular adrenocortical disease 1 | Alliance | Pigmented nodular adrenocortical disease, primary, 1 | 610489 |
Adrenocortical tumor, somatic | |||
Myxoma, intracardiac | 255960 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
Domain | IPR000595 | Cyclic nucleotide-binding domain |
Domain | IPR003117 | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain |
Family | IPR012198 | cAMP-dependent protein kinase regulatory subunit |
Family | IPR050503 | cAMP-dependent kinase regulatory chain |
Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
Protein | Length | cAMP-dependent kinase regulatory chain | cAMP-dependent protein kinase regulatory subunit | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | RmlC-like jelly roll fold |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q567D1
|
379 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
prkar1ab-201
(1)
|
Ensembl | 1,829 nt |
Interactions and Pathways
No data available
Plasmids
No data available