Gene

prkar1ab

ID
ZDB-GENE-050417-238
Name
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b
Symbol
prkar1ab Nomenclature History
Previous Names
  • zgc:112145
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cGMP-mediated signaling. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prkar1ab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acrodysostosis Alliance Acrodysostosis 1, with or without hormone resistance 101800
Carney complex Alliance Carney complex, type 1 160980
primary pigmented nodular adrenocortical disease 1 Alliance Pigmented nodular adrenocortical disease, primary, 1 610489
Adrenocortical tumor, somatic
Myxoma, intracardiac 255960
Associated With prkar1ab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018488 Cyclic nucleotide-binding, conserved site
Domain IPR000595 Cyclic nucleotide-binding domain
Domain IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
Family IPR012198 cAMP-dependent protein kinase regulatory subunit
Family IPR050503 cAMP-dependent kinase regulatory chain
Homologous_superfamily IPR014710 RmlC-like jelly roll fold
Homologous_superfamily IPR018490 Cyclic nucleotide-binding domain superfamily
Domain Details Per Protein
Protein Length cAMP-dependent kinase regulatory chain cAMP-dependent protein kinase regulatory subunit cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain Cyclic nucleotide-binding, conserved site Cyclic nucleotide-binding domain Cyclic nucleotide-binding domain superfamily RmlC-like jelly roll fold
UniProtKB:Q567D1 379
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA prkar1ab-201 (1) Ensembl 1,829 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations