Gene
bbox1
- ID
- ZDB-GENE-050417-218
- Name
- butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
- Symbol
- bbox1 Nomenclature History
- Previous Names
-
- wu:fj14g08
- zgc:112179
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable gamma-butyrobetaine dioxygenase activity. Predicted to be involved in carnitine biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in male organism. Orthologous to human BBOX1 (gamma-butyrobetaine hydroxylase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112179 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa45283 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003819 | TauD/TfdA-like domain |
| Domain | IPR010376 | Gamma-butyrobetaine hydroxylase-like, N-terminal |
| Family | IPR012775 | Gamma-butyrobetaine hydroxylase-like |
| Family | IPR050411 | Alpha-ketoglutarate-dependent hydroxylases |
| Homologous_superfamily | IPR038492 | GBBH-like, N-terminal domain superfamily |
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Domain Details Per Protein
| Protein | Length | Alpha-ketoglutarate-dependent hydroxylases | Gamma-butyrobetaine hydroxylase-like | Gamma-butyrobetaine hydroxylase-like, N-terminal | GBBH-like, N-terminal domain superfamily | TauD/TfdA-like domain | Taurine dioxygenase TauD-like superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q567B2
|
325 | ||||||
|
UniProtKB:A0A1D5NSC9
|
433 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-98N17 | ZFIN Curated Data | |
| Contained in | BAC | CH211-198A3 | ||
| Encodes | EST | fj14g08 | ||
| Encodes | cDNA | MGC:112179 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017717 (1) | 2218 nt | ||
| Genomic | GenBank:CR318654 (1) | 233169 nt | ||
| Polypeptide | UniProtKB:A0A1D5NSC9 (1) | 433 aa |
- Tai, Z., Guan, P., Wang, Z., Li, L., Zhang, T., Li, G., Liu, J.X. (2019) Common responses of fish embryos to metals: an integrated analysis of transcriptomes and methylomes in zebrafish embryos under the stress of copper ions or silver nanoparticles. Metallomics : integrated biometal science. 11(9):1452-1464
- Li, J.M., Li, L.Y., Qin, X., Degrace, P., Demizieux, L., Limbu, S.M., Wang, X., Zhang, M.L., Li, D.L., Du, Z.Y. (2018) Inhibited Carnitine Synthesis Causes Systemic Alteration of Nutrient Metabolism in Zebrafish. Frontiers in Physiology. 9:509
- Li, J.M., Li, L.Y., Qin, X., Ning, L.J., Lu, D.L., Li, D.L., Zhang, M.L., Wang, X., Du, Z.Y. (2017) Systemic regulation of L-carnitine in nutritional metabolism in zebrafish, Danio rerio. Scientific Reports. 7:40815
- Wakahara, T., Kusu, N., Yamauchi, H., Kimura, I., Konishi, M., Miyake, A., and Itoh, N. (2007) fibin, a novel secreted lateral plate mesoderm signal, is essential for pectoral fin bud initiation in zebrafish. Developmental Biology. 303(2):527-535
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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