Gene
lhx9
- ID
- ZDB-GENE-050417-210
- Name
- LIM homeobox 9
- Symbol
- lhx9 Nomenclature History
- Previous Names
-
- si:dkey-121a9.2
- zgc:112196
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within neuron fate specification and thalamus development. Predicted to be active in nucleus. Is expressed in several structures, including brain; forebrain neural keel; hypocretin-secreting neurons; pericardial region; and retina. Orthologous to human LHX9 (LIM homeobox 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | LIM/homeobox transcription factors | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A2U3TWB7
|
330 | |||||
|
UniProtKB:Q1LWV4
|
396 | |||||
|
UniProtKB:A0A8M9PJJ4
|
395 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-121A9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:112196 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194498 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194712 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194727 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001037243 (1) | 2991 nt | ||
| Genomic | GenBank:BX004971 (2) | 199780 nt | ||
| Polypeptide | UniProtKB:Q1LWV4 (1) | 396 aa |
- Brożko, N., Baggio, S., Lipiec, M.A., Jankowska, M., Szewczyk, Ł.M., Gabriel, M.O., Chakraborty, C., Ferran, J.L., Wiśniewska, M.B. (2022) Genoarchitecture of the Early Postmitotic Pretectum and the Role of Wnt Signaling in Shaping Pretectal Neurochemical Anatomy in Zebrafish. Frontiers in Neuroanatomy. 16:838567
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Guo, R., Li, F., Lu, M., Ge, K., Gan, L., Sheng, D. (2021) LIM Homeobox 9 Knockdown by Morpholino does not Affect Zebrafish Retinal Development. Biology Open. 10(3):
- Fernandes, A.M., Mearns, D.S., Donovan, J.C., Larsch, J., Helmbrecht, T.O., Kölsch, Y., Laurell, E., Kawakami, K., Dal Maschio, M., Baier, H. (2020) Neural circuitry for stimulus selection in the zebrafish visual system. Neuron. 109(5):805-822.e6
- Schredelseker, T., Driever, W. (2020) Conserved Genoarchitecture of the Basal Hypothalamus in Zebrafish Embryos. Frontiers in Neuroanatomy. 14:3
- Schredelseker, T., Veit, F., Dorsky, R.I., Driever, W. (2020) Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. Frontiers in neuroscience. 14:525
- Ladam, F., Stanney, W., Donaldson, I.J., Yildiz, O., Bobola, N., Sagerström, C.G. (2018) TALE factors use two distinct functional modes to control an essential zebrafish gene expression program. eLIFE. 7
- Shimizu, N., Matsuda, M. (2018) Identification of a Novel Zebrafish Mutant Line that Develops Testicular Germ Cell Tumors. Zebrafish. 16(1):15-28
- Förster, D., Arnold-Ammer, I., Laurell, E., Barker, A.J., Fernandes, A.M., Finger-Baier, K., Filosa, A., Helmbrecht, T.O., Kölsch, Y., Kühn, E., Robles, E., Slanchev, K., Thiele, T.R., Baier, H., Kubo, F. (2017) Genetic targeting and anatomical registration of neuronal populations in the zebrafish brain with a new set of BAC transgenic tools. Scientific Reports. 7:5230
- Loponte, S., Segré, C.V., Senese, S., Miccolo, C., Santaguida, S., Deflorian, G., Citro, S., Mattoscio, D., Pisati, F., Moser, M.A., Visintin, R., Seiser, C., Chiocca, S. (2016) Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development. Scientific Reports. 6:30213
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