Gene
eif2ak3
- ID
- ZDB-GENE-050414-2
- Name
- eukaryotic translation initiation factor 2-alpha kinase 3
- Symbol
- eif2ak3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have eukaryotic translation initiation factor 2alpha kinase activity. Involved in response to endoplasmic reticulum stress and response to hypoxia. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Is expressed in brain and liver. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Wolcott-Rallison syndrome | Alliance | Wolcott-Rallison syndrome | 226980 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR050339 | Cell Cycle and Stress Response Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011047 | Quinoprotein alcohol dehydrogenase-like superfamily |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
Domain Details Per Protein
| Protein | Length | Cell Cycle and Stress Response Kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Quinoprotein alcohol dehydrogenase-like superfamily | Serine/threonine-protein kinase, active site | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B3B8
|
1099 | |||||||
|
UniProtKB:B8JI14
|
1099 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eif2ak3-201
(1)
|
Ensembl | 1,675 nt | ||
| mRNA |
eif2ak3-202
(1)
|
Ensembl | 3,970 nt | ||
| ncRNA |
eif2ak3-003
(1)
|
Ensembl | 580 nt |
Interactions and Pathways
No data available
Plasmids
No data available