Gene
parla
- ID
- ZDB-GENE-050327-8
- Name
- presenilin associated, rhomboid-like a
- Symbol
- parla Nomenclature History
- Previous Names
-
- parlb (2)
- zgc:112986
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have serine-type endopeptidase activity. Predicted to be involved in regulation of mitochondrion organization. Predicted to localize to mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Is expressed in brain and liver. Orthologous to human PARL (presenilin associated rhomboid like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112986 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Noble et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Peptidase S54, rhomboid domain | Rhomboid-like superfamily | Rhomboid protease S54 |
|---|---|---|---|---|
|
UniProtKB:A0A8M3AN93
|
195 | |||
|
UniProtKB:A0A8M9PWK1
|
318 | |||
|
UniProtKB:B2GQL1
|
383 | |||
|
UniProtKB:A0A8M3AN88
|
280 | |||
|
UniProtKB:Q58EK4
|
383 |
Interactions and Pathways
No data available
Plasmids
No data available