Gene

kcnab1a

ID

ZDB-GENE-050327-79

Name

potassium voltage-gated channel subfamily A regulatory beta subunit 1a

Symbol

kcnab1a Nomenclature History

Previous Names

kcnab1
zgc:113627 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable aldo-keto reductase (NADP) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in negative regulation of delayed rectifier potassium channel activity. Predicted to act upstream of or within potassium ion transport; regulation of monoatomic ion transmembrane transport; and transmembrane transport. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in juxtaparanode region of axon. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in immature eye; myotome; nervous system; pharyngeal arch; and somite. Human ortholog(s) of this gene implicated in temporal lobe epilepsy. Orthologous to human KCNAB1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7159135 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnab1a Human Ortholog

No data available

Associated With kcnab1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR023210	NADP-dependent oxidoreductase domain
Family	IPR005399	Potassium channel, voltage-dependent, beta subunit, KCNAB-related
Family	IPR005400	Potassium channel, voltage-dependent, beta subunit, KCNAB1
Family	IPR005983	Potassium channel, voltage-dependent, beta subunit, KCNAB
Homologous_superfamily	IPR036812	NADP-dependent oxidoreductase domain superfamily

Domain Details Per Protein

Protein	Length	NADP-dependent oxidoreductase domain	NADP-dependent oxidoreductase domain superfamily	Potassium channel, voltage-dependent, beta subunit, KCNAB	Potassium channel, voltage-dependent, beta subunit, KCNAB1	Potassium channel, voltage-dependent, beta subunit, KCNAB-related
UniProtKB:Q58EC4 InterPro	398
UniProtKB:A0A8M9PQ73 InterPro	403
UniProtKB:A0A8M9PM35 InterPro	423
UniProtKB:A0A8M9PFF1 InterPro	406
UniProtKB:A0A8M9P126 InterPro	418
UniProtKB:A0A8M9PA23 InterPro	411