Gene
nsd3
- ID
- ZDB-GENE-050324-2
- Name
- nuclear receptor binding SET domain protein 3
- Symbol
- nsd3 Nomenclature History
- Previous Names
-
- whsc1l1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have histone methyltransferase activity (H3-K36 specific). Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to chromatin and nucleus. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to human NSD3 (nuclear receptor binding SET domain protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sun et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR000313 | PWWP domain |
| Domain | IPR001214 | SET domain |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR003616 | Post-SET domain |
| Domain | IPR006560 | AWS domain |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR041306 | NSD, Cys-His rich domain |
| Domain | IPR047451 | Histone-lysine N-methyltransferase NSD3, first PWWP domain |
| Domain | IPR047453 | Histone-lysine N-methyltransferase NSD3, second PWWP domain |
| Domain | IPR047458 | Histone-lysine N-methyltransferase NSD3, fourth PHD finger |
| Domain | IPR047527 | Histone-lysine N-methyltransferase NSD3, fifth PHD finger |
| Family | IPR050777 | SET2 Histone-Lysine N-Methyltransferase |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | AWS domain | Histone-lysine N-methyltransferase NSD3, fifth PHD finger | Histone-lysine N-methyltransferase NSD3, first PWWP domain | Histone-lysine N-methyltransferase NSD3, fourth PHD finger | Histone-lysine N-methyltransferase NSD3, second PWWP domain | NSD, Cys-His rich domain | Post-SET domain | PWWP domain | SET2 Histone-Lysine N-Methyltransferase | SET domain | SET domain superfamily | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B1N3
|
1563 | ||||||||||||||||
|
UniProtKB:A0A8M2B1H9
|
1521 | ||||||||||||||||
|
UniProtKB:F1QV68
|
1513 |
Interactions and Pathways
No data available
Plasmids
No data available