Gene
hsp70l
- ID
- ZDB-GENE-050321-1
- Name
- heat shock cognate 70-kd protein, like
- Symbol
- hsp70l Nomenclature History
- Previous Names
-
- hsp70-4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Acts upstream of or within several processes, including definitive hemopoiesis; response to cadmium ion; and response to heat. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in lens. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1A (heat shock protein family A (Hsp70) member 1A); and HSPA1B (heat shock protein family A (Hsp70) member 1B).
- Genome Resources
- Note
-
The promoter region of this gene is used in most "hsp70" transgenic lines.
- Comparative Information
-
- All Expression Data
- 23 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018181 | Heat shock protein 70, conserved site |
| Family | IPR013126 | Heat shock protein 70 family |
| Homologous_superfamily | IPR029047 | Heat shock protein 70kD, peptide-binding domain superfamily |
| Homologous_superfamily | IPR029048 | Heat shock protein 70kD, C-terminal domain superfamily |
| Homologous_superfamily | IPR043129 | ATPase, nucleotide binding domain |
Domain Details Per Protein
| Protein | Length | ATPase, nucleotide binding domain | Heat shock protein 70, conserved site | Heat shock protein 70 family | Heat shock protein 70kD, C-terminal domain superfamily | Heat shock protein 70kD, peptide-binding domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A8WFS0
|
643 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hsp70l-201
(1)
|
Ensembl | 2,302 nt |
Interactions and Pathways
No data available
Plasmids