Gene
c6ast3
- ID
- ZDB-GENE-050320-99
- Name
- six-cysteine containing astacin protease 3
- Symbol
- c6ast3 Nomenclature History
- Previous Names
-
- zgc:103606 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Predicted to act upstream of or within proteolysis. Orthologous to human ASTL (astacin like metalloendopeptidase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103606 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Metallopeptidase, catalytic domain superfamily | Peptidase M12A | Peptidase, metallopeptidase |
|---|---|---|---|---|
|
UniProtKB:Q5BKW6
|
255 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
c6ast3-202
(1)
|
Ensembl | 880 nt | ||
| mRNA |
c6ast3-201
(1)
|
Ensembl | 920 nt | ||
| mRNA |
c6ast3-203
(1)
|
Ensembl | 765 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-150L7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103606 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192537 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013526 (1) | 920 nt | ||
| Genomic | GenBank:BX957297 (1) | 79980 nt | ||
| Polypeptide | UniProtKB:Q5BKW6 (1) | 255 aa |
No data available
- Lin, Q., Fan, S., Zhang, Y., Xu, M., Zhang, H., Yang, Y., Lee, A.P., Woltering, J.M., Ravi, V., Gunter, H.M., Luo, W., Gao, Z., Lim, Z.W., Qin, G., Schneider, R.F., Wang, X., Xiong, P., Li, G., Wang, K., Min, J., Zhang, C., Qiu, Y., Bai, J., He, W., Bian, C., Zhang, X., Shan, D., Qu, H., Sun, Y., Gao, Q., Huang, L., Shi, Q., Meyer, A., Venkatesh, B. (2016) The seahorse genome and the evolution of its specialized morphology. Nature. 540:395-399
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kim, S., Carrillo, M., Kulkarni, V., and Jagadeeswaran, P. (2009) Evolution of primary hemostasis in early vertebrates. PLoS One. 4(12):e8403
- Kawaguchi, M., Yasumasu, S., Hiroi, J., Naruse, K., Inoue, M., and Iuchi, I. (2006) Evolution of teleostean hatching enzyme genes and their paralogous genes. Development genes and evolution. 216(12):769-784
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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