Gene
smyd2a
- ID
- ZDB-GENE-050320-126
- Name
- SET and MYND domain containing 2a
- Symbol
- smyd2a Nomenclature History
- Previous Names
-
- smyd2
- im:7146196
- wu:fc02f02
- zgc:110553
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II complex binding activity and histone H3K36 methyltransferase activity. Acts upstream of or within several processes, including caudal fin development; heart contraction; and regulation of sarcomere organization. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in heart primordium; muscle cell; and somite. Orthologous to human SMYD2 (SET and MYND domain containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7146196 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Histone-lysine N-methyltransferase | SET domain | SET domain superfamily | Tetratricopeptide-like helical domain superfamily | Zinc finger, MYND-type |
|---|---|---|---|---|---|---|
|
UniProtKB:Q5BJI7
|
435 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
smyd2a-201
(1)
|
Ensembl | 2,197 nt | ||
| ncRNA |
smyd2a-002
(1)
|
Ensembl | 578 nt | ||
| ncRNA |
smyd2a-003
(1)
|
Ensembl | 462 nt | ||
| ncRNA |
smyd2a-004
(1)
|
Ensembl | 551 nt | ||
| ncRNA |
smyd2a-005
(1)
|
Ensembl | 811 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-152H14 | ZFIN Curated Data | |
| Encodes | EST | fc02f02 | ||
| Encodes | EST | IMAGE:7142251 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7146196 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:110553 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013550 (1) | 2057 nt | ||
| Genomic | GenBank:BX936381 (1) | 156270 nt | ||
| Polypeptide | UniProtKB:Q5BJI7 (1) | 435 aa |
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- She, P., Zhang, H., Peng, X., Sun, J., Gao, B., Zhou, Y., Zhu, X., Hu, X., Lai, K.S., Wong, J., Zhou, B., Wang, L., Zhong, T.P. (2020) The Gridlock transcriptional repressor impedes vertebrate heart regeneration by restricting expression of lysine methyltransferase. Development (Cambridge, England). 147(18):
- Fellous, A., Earley, R.L., Silvestre, F. (2018) The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Gene. 687:173-187
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kim, J.D., Kim, E., Koun, S., Ham, H.J., Rhee, M., Kim, M.J., Huh, T.L. (2015) Proper Activity of Histone H3 Lysine 4 (H3K4) Methyltransferase Is Required for Morphogenesis during Zebrafish Cardiogenesis. Molecules and cells. 38(6):580-6
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Sesé, B., Barrero, M.J., Fabregat, M.C., Sander, V., and Izpisua Belmonte, J.C. (2013) SMYD2 is induced during cell differentiation and participates in early development. The International journal of developmental biology. 57(5):357-364
- Voelkel, T., Andresen, C., Unger, A., Just, S., Rottbauer, W., and Linke, W.A. (2013) Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function. Biochimica et biophysica acta. Molecular cell research. 1833(4):812-822
- Donlin, L.T., Andresen, C., Just, S., Rudensky, E., Pappas, C.T., Kruger, M., Jacobs, E.Y., Unger, A., Zieseniss, A., Dobenecker, M.W., Voelkel, T., Chait, B.T., Gregorio, C.C., Rottbauer, W., Tarakhovsky, A., and Linke, W.A. (2012) Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization. Genes & Development. 26(2):114-119
- Sun, X.J., Xu, P.F., Zhou, T., Hu, M., Fu, C.T., Zhang, Y., Jin, Y., Chen, Y., Chen, S.J., Huang, Q.H., Liu, T.X., and Chen, Z. (2008) Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes. PLoS One. 3(1):e1499
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