Gene
dnmt3aa
- ID
- ZDB-GENE-050314-5
- Name
- DNA (cytosine-5-)-methyltransferase 3 alpha a
- Symbol
- dnmt3aa Nomenclature History
- Previous Names
-
- dnmt3a2 (1)
- dnmt8
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have DNA-methyltransferase activity. Predicted to be involved in DNA methylation and regulation of gene expression. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; acute lymphoblastic leukemia; acute myeloid leukemia; myelodysplastic syndrome; and stomach cancer. Is expressed in several structures, including digestive system; nervous system; pleuroperitoneal region; spinal cord neural tube; and swim bladder bud. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | Acute myeloid leukemia, somatic | 601626 |
| Tatton-Brown-Rahman syndrome | Alliance | Tatton-Brown-Rahman syndrome | 615879 |
| Heyn-Sproul-Jackson syndrome | 618724 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018117 | DNA methylase, C-5 cytosine-specific, active site |
| Domain | IPR000313 | PWWP domain |
| Domain | IPR025766 | ADD domain |
| Domain | IPR040552 | DNMT3, cysteine rich ADD domain, GATA1-like zinc finger |
| Domain | IPR044108 | DNA (cytosine-5)-methyltransferase 3A, ADD domain |
| Domain | IPR049554 | DNMT3, ADD domain, PHD zinc finger |
| Family | IPR001525 | C-5 cytosine methyltransferase |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
Domain Details Per Protein
| Protein | Length | ADD domain | C-5 cytosine methyltransferase | DNA (cytosine-5)-methyltransferase 3A, ADD domain | DNA methylase, C-5 cytosine-specific, active site | DNMT3, ADD domain, PHD zinc finger | DNMT3, cysteine rich ADD domain, GATA1-like zinc finger | PWWP domain | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q588C2
|
852 | ||||||||
|
UniProtKB:A0A8M2B825
|
1010 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dnmt3aa-201
(1)
|
Ensembl | 2,905 nt | ||
| mRNA |
dnmt3aa-202
(1)
|
Ensembl | 557 nt |
Interactions and Pathways
No data available
Plasmids
No data available