Gene

gstm.3

ID

ZDB-GENE-050309-24

Name

glutathione S-transferase mu tandem duplicate 3

Symbol

gstm.3 Nomenclature History

Previous Names

gstm3 (1)
im:6897516

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Exhibits glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Human ortholog(s) of this gene implicated in several diseases, including central nervous system cancer (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Is expressed in brain; gill; liver; and pleuroperitoneal region. Orthologous to several human genes including GSTM1 (glutathione S-transferase mu 1); GSTM2 (glutathione S-transferase mu 2); and GSTM3 (glutathione S-transferase mu 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Juang et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gstm.3 Human Ortholog

No data available

Associated With gstm.3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Brugada syndrome	gstm.3^{zf3368/zf3368}	standard conditions	Juang et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004045	Glutathione S-transferase, N-terminal
Domain	IPR004046	Glutathione S-transferase, C-terminal
Domain	IPR010987	Glutathione S-transferase, C-terminal-like
Family	IPR003081	Glutathione S-transferase, Mu class
Family	IPR040079	Glutathione transferase family
Family	IPR050213	Glutathione S-transferase superfamily
Homologous_superfamily	IPR036249	Thioredoxin-like superfamily
Homologous_superfamily	IPR036282	Glutathione S-transferase, C-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Glutathione S-transferase, C-terminal	Glutathione S-transferase, C-terminal domain superfamily	Glutathione S-transferase, C-terminal-like	Glutathione S-transferase, Mu class	Glutathione S-transferase, N-terminal	Glutathione S-transferase superfamily	Glutathione transferase family	Thioredoxin-like superfamily
UniProtKB:B8JIS5 InterPro	219

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gstm.3-201 (1) Ensembl	Ensembl	1,603 nt	Select Tool ZFIN BLAST
mRNA	gstm.3-203 (1) Ensembl	Ensembl	1,001 nt	Select Tool ZFIN BLAST
ncRNA	gstm.3-003 (1) Ensembl	Ensembl	1,125 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations