Gene

dlg1b

ID

ZDB-GENE-050222-3

Name

discs large MAGUK scaffold protein 1b

Symbol

dlg1b Nomenclature History

Previous Names

dlg1l
SAP-97B (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have phosphatase binding activity and protein kinase binding activity. Predicted to be involved in several processes, including actin cytoskeleton organization; endothelial cell proliferation; and establishment or maintenance of epithelial cell apical/basal polarity. Predicted to colocalize with ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Is expressed in retina; spinal cord; and tegmentum. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu269 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dlg1b Human Ortholog

No data available

Associated With dlg1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020590	Guanylate kinase, conserved site
Domain	IPR001452	SH3 domain
Domain	IPR001478	PDZ domain
Domain	IPR004172	L27 domain
Domain	IPR008144	Guanylate kinase-like domain
Domain	IPR008145	Guanylate kinase/L-type calcium channel beta subunit
Domain	IPR015143	L27-1
Domain	IPR019583	Disks large homolog 1-4, PDZ-associated domain
Domain	IPR019590	Disks large homologue 1, N-terminal PEST domain
Family	IPR016313	Disks large 1-like
Family	IPR050614	Synaptic Scaffolding LAP/MAGUK Families
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily
Homologous_superfamily	IPR036892	L27 domain superfamily

Domain Details Per Protein

Protein	Length	Disks large 1-like	Disks large homolog 1-4, PDZ-associated domain	Disks large homologue 1, N-terminal PEST domain	Guanylate kinase, conserved site	Guanylate kinase-like domain	Guanylate kinase/L-type calcium channel beta subunit	L27-1	L27 domain	L27 domain superfamily	PDZ domain	PDZ superfamily	P-loop containing nucleoside triphosphate hydrolase	SH3 domain	SH3-like domain superfamily	Synaptic Scaffolding LAP/MAGUK Families
UniProtKB:Q5PYH5 InterPro	827
UniProtKB:A0A8M3AVI6 InterPro	955
UniProtKB:A0A8M9QIS4 InterPro	763
UniProtKB:A0A8M3AN11 InterPro	990
UniProtKB:A0A8M3ANR6 InterPro	969
UniProtKB:A0A0R4IEK3 InterPro	906
UniProtKB:A0A8M3AN35 InterPro	950
UniProtKB:A0A8M2BB01 InterPro	918
UniProtKB:A0A8M3B6A9 InterPro	820
UniProtKB:A0A8M2BB75 InterPro	894
UniProtKB:A0A8M2BAW9 InterPro	927
UniProtKB:A0A8M2BAT2 InterPro	873
UniProtKB:A0A8M3B688 InterPro	966
UniProtKB:A0A8M2BAT6 InterPro	957
UniProtKB:A0A8M3AYM3 InterPro	911
UniProtKB:A0A8M9Q8G6 InterPro	871
UniProtKB:A0A8M9QMI5 InterPro	989
UniProtKB:A0A8M2BB05 InterPro	736
UniProtKB:A0A8M2BB74 InterPro	951
UniProtKB:A0A8M2BAX2 InterPro	841
UniProtKB:A0A8M2BAS7 InterPro	950
UniProtKB:A0A8M3ANU0 InterPro	836

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	dlg1l-206 (1) Ensembl	Ensembl	2,598 nt	Select Tool
mRNA	dlg1l-202 (1) Ensembl	Ensembl	672 nt	Select Tool
mRNA	dlg1l-204 (1) Ensembl	Ensembl	6,958 nt	Select Tool
mRNA	dlg1l-205 (1) Ensembl	Ensembl	2,964 nt	Select Tool
mRNA	dlg1l-208 (1) Ensembl	Ensembl	183 nt	Select Tool ZFIN BLAST
ncRNA	dlg1l-003 (1) Ensembl	Ensembl	796 nt	Select Tool
ncRNA	dlg1l-004 (1) Ensembl	Ensembl	614 nt	Select Tool
ncRNA	dlg1l-007 (1) Ensembl	Ensembl	890 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations