Gene
crabp2b
- ID
- ZDB-GENE-050208-52
- Name
- cellular retinoic acid binding protein 2, b
- Symbol
- crabp2b Nomenclature History
- Previous Names
-
- im:7136989
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable fatty acid binding activity. Acts upstream of or within hindbrain morphogenesis and regulation of retinoic acid receptor signaling pathway. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including eye; neural keel; neural plate; optic vesicle; and pectoral fin. Orthologous to human CRABP2 (cellular retinoic acid binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136989 (22 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Calycin | Cytosolic fatty-acid binding | Intracellular lipid binding protein | Lipocalin/cytosolic fatty-acid binding domain |
---|---|---|---|---|---|
UniProtKB:Q5G9L7
|
146 | ||||
UniProtKB:A4VCG2
|
146 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
crabp2b-201
(1)
|
Ensembl | 3,535 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-262M20 | ZFIN Curated Data | |
Contained in | BAC | CH211-12C3 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7136989 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:162511 | ZFIN Curated Data | |
Has Artifact | EST | fc87g11 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001320394 (1) | 902 nt | ||
Genomic | GenBank:CU464180 (1) | 45057 nt | ||
Polypeptide | UniProtKB:A4VCG2 (1) | 146 aa |
- Greenfeld, H., Lin, J., Mullins, M.C. (2021) The BMP signaling gradient is interpreted through concentration thresholds in dorsal-ventral axial patterning. PLoS Biology. 19:e3001059
- Rogers, K.W., ElGamacy, M., Jordan, B.M., Müller, P. (2020) Optogenetic investigation of BMP target gene expression diversity. eLIFE. 9:
- Hurem, S., Martín, L.M., Brede, D.A., Skjerve, E., Nourizadeh-Lillabadi, R., Lind, O.C., Christensen, T., Berg, V., Teien, H.C., Salbu, B., Oughton, D.H., Aleström, P., Lyche, J.L. (2017) Dose-dependent effects of gamma radiation on the early zebrafish development and gene expression. PLoS One. 12:e0179259
- Hurem, S., Martín, L.M., Lindeman, L., Brede, D.A., Salbu, B., Lyche, J.L., Aleström, P., Kamstra, J.H. (2017) Parental exposure to gamma radiation causes progressively altered transcriptomes linked to adverse effects in zebrafish offspring. Environmental pollution (Barking, Essex : 1987). 234:855-863
- Yan, S., Lu, Y., He, L., Zhao, X., Wu, L., Zhu, H., Jiang, M., Su, Y., Cao, W., Tian, W., Xing, Q. (2017) Dynamic Editome of Zebrafish under Aminoglycosides Treatment and Its Potential Involvement in Ototoxicity. Frontiers in pharmacology. 8:854
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kujawski, S., Lin, W., Kitte, F., Börmel, M., Fuchs, S., Arulmozhivarman, G., Vogt, S., Theil, D., Zhang, Y., Antos, C.L. (2014) Calcineurin regulates coordinated outgrowth of zebrafish regenerating fins. Developmental Cell. 28:573-87
- Parmar, M.B., Lee, J.J., and Wright, J.M. (2013) Duplicated crabp1 and crabp2 genes in medaka (Oryzias latipes): Gene structure, phylogenetic relationship and tissue-specific distribution of transcripts. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 165(1):10-8
- Cai, A.Q., Radtke, K., Linville, A., Lander, A.D., Nie, Q., and Schilling, T.F. (2012) Cellular retinoic acid-binding proteins are essential for hindbrain patterning and signal robustness in zebrafish. Development (Cambridge, England). 139(12):2150-2155
- Hughes, A.L., and Piontkivska, H. (2011) Evolutionary diversification of the avian fatty acid-binding proteins. Gene. 490(1-2):1-5
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